BIOMAT Database Logo BIOMAT Database Logo

Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas. 1998

H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Division of a Medical Genetics, Harbor-UCLA Medical Centre, Torrance, USA. henry.linhumc.edu

N-acetyltransferase NAT1, together with enzymes CYP1A2 and NAT2, helps convert heterocyclic amines to mutagens. Epidemiologic studies of the association of variants of these enzymes with colorectal cancer may provide indirect support for a heterocyclic amine mechanism. We used single strand conformation polymorphism and heteroduplex analysis to screen fro mutations in the NAT1 coding region in a case-control study (n = 932) of colorectal adenomas, which are precursors to cancer. Thirteen different single-base mutations were found: C97T, C190T, T402C, G445A-G459A-T640G ( a combination of three mutations), C559T, G560A, A613G, A752T, T777C, G781A, and A787G. Function of novel mutations was tested by bacterial production of enzymes and measurements of Km, Vmax, and stability. However, on 24-control individuals and 18 cases carried an inactivating NAT1 mutation. When combined with our data on the NAT2 acetylation polymorphism, we saw no evidence for an association between N-acetyltransferases and prevalence of adenomas. Larger sample sizes are required for further evaluation.

UI MeSH Term Description Entries
D007527 Isoenzymes Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics. Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D002140 California State bounded on the east by Nevada and Arizona, on the south by Mexico and the Pacific Ocean on the south and west, and on the north by Oregon.
D004795 Enzyme Stability The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat. Enzyme Stabilities,Stabilities, Enzyme,Stability, Enzyme
D005006 Ethnicity A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships. Ethnic Groups,Nationality,Ethnic Group,Nationalities
D005820 Genetic Testing Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing. Genetic Predisposition Testing,Genetic Screening,Predictive Genetic Testing,Predictive Testing, Genetic,Testing, Genetic Predisposition,Genetic Predictive Testing,Genetic Screenings,Genetic Testing, Predictive,Predisposition Testing, Genetic,Screening, Genetic,Screenings, Genetic,Testing, Genetic,Testing, Genetic Predictive,Testing, Predictive Genetic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000123 Acetyltransferases Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compound. EC 2.3.1. Acetyltransferase
D000236 Adenoma A benign epithelial tumor with a glandular organization. Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas

Related Publications

H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1.
August 2000, Molecular pharmacology,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study.
January 2002, Environmental and molecular mutagenesis,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Smoking and colorectal adenomas: a case-control study.
June 2000, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP),
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Colorectal adenomas and diet: a case-control study. Colorectal Adenoma Study Group.
January 2001, Digestive diseases and sciences,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.
October 2018, Pharmacogenetics and genomics,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Genotyping human arylamine N-acetyltransferase type 1 (NAT1): the identification of two novel allelic variants.
February 1998, Biochemical pharmacology,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development.
November 2008, Genes to cells : devoted to molecular & cellular mechanisms,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Diet and colorectal adenomas: a case-control study in Majorca.
September 1993, International journal of cancer,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population.
February 2000, Pharmacogenetics,
H J Lin, and N M Probst-Hensch, and N C Hughes, and G T Sakamoto, and A D Louie, and I H Kau, and B K Lin, and D B Lee, and J Lin, and H D Frankl, and E R Lee, and S Hardy, and D M Grant, and R W Haile
N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk.
August 1998, Pharmacogenetics,
Copied contents to your clipboard!