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1. The interaction between nitric oxide (NO) and superoxide anions has received a great deal of attention. Because NO is rapidly inactivated by superoxide anions, it has been suggested that an enhanced formation of this radical may be involved in the accelerated breakdown of NO. 2. In the present study, we administrated glyburide (glibenclamide) to Streptozotocin-induced diabetic rats and determined the effect of such treatment on serum nitrite+nitrate levels. Serum nitrite+nitrate levels were reduced in diabetic animals (P<0.001). Administration of glyburide to diabetic rats reversed the diabetes-induced changes, suggesting that glyburide may directly increase serum nitrite+nitrate levels.
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
May 1997,
General pharmacology,
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
March 1998,
General pharmacology,
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
November 1994,
General pharmacology,
N Altan, and
G Buğdayci, and
F K Tutkun, and
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N K Nazaroğlu
December 2006,
Acta diabetologica,
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
January 1994,
Diabetes research and clinical practice,
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
October 1994,
General pharmacology,
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
September 1994,
General pharmacology,
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
January 2009,
Journal of diabetes and its complications,
N Altan, and
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F K Tutkun, and
B Sancak, and
N K Nazaroğlu
August 1998,
Brain research bulletin,
N Altan, and
G Buğdayci, and
F K Tutkun, and
B Sancak, and
N K Nazaroğlu
September 2001,
The Journal of laboratory and clinical medicine,
