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Smoke inhalation dosimetry studies have been carried out on rats, using a new exposure system. A range of cigarettes, tobacco types and smoke concentrations was used. Penetration of smoke into the lungs was clearly demonstrated, and loads of total particulate matter (TPM) of up 1 mg were detected in the lower respiratory system of rats. The mass of TPM deposited was affected by the smoke concentration during exposure. Deposition of TPM in the head of the rat was low in relation to total respiratory system deposition. A pattern of predominantly lung deposition was achieved under the conditions used for this series of experiments. This pattern was not affected by changes in smoke dilution level, cigarette or tobacco type.
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
January 1976,
Toxicology,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
September 1976,
Toxicology and applied pharmacology,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
July 1997,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
January 1984,
Archives of environmental health,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
February 1978,
Toxicology,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
January 1975,
Reviews on environmental health,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
September 2017,
Cadernos de saude publica,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
January 2000,
Toxicologic pathology,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
October 1981,
Toxicology and applied pharmacology,
R Binns, and
J L Beven, and
L V Wilton, and
W G Lugton
February 1969,
Arzneimittel-Forschung,
