Biomaterial Database

Disclosure of novel autoantigens in human autoimmunity . 1998

R Mirakian, and M Locatelli, and G F Bottazzo

Department of Immunology, St Bartholomew's and Royal London School of Medicine and Dentistry, UK.

UI	MeSH Term	Description	Entries
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001323	Autoantibodies	Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.	Autoantibody
D001324	Autoantigens	Endogenous tissue constituents with the ability to interact with AUTOANTIBODIES and cause an immune response.	Autoantigen,Autologous Antigen,Autologous Antigens,Self-Antigen,Self-Antigens,Antigen, Autologous,Antigens, Autologous,Self Antigen,Self Antigens
D001327	Autoimmune Diseases	Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune
D014365	Tryptophan Hydroxylase	An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.	Tryptophan Monooxygenase,Hydroxylase, Tryptophan,Monooxygenase, Tryptophan
D016884	Polyendocrinopathies, Autoimmune	Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.	Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy,Autoimmune Syndrome Type I, Polyglandular,Autoimmune Syndrome Type II, Polyglandular,Polyglandular Type I Autoimmune Syndrome,Polyglandular Type II Autoimmune Syndrome,Schmidt's Syndrome,AIRE Deficiency,APECED,APS Type 1,Autoimmune Polyendocrine Syndrome, Type 2,Autoimmune Polyendocrine Syndrome, Type II,Autoimmune Polyendocrinopathy Syndrome Type 1,Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy,Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy,Autoimmune Polyglandular Syndrome Type I,Autoimmune Polyglandular Syndrome Type II,Autoimmune Polyglandular Syndrome Type III,Autoimmune Polyglandular Syndrome, Type 1,Autoimmune Polyglandular Syndrome, Type 3,Autoimmune Polyglandular Syndrome, Type I,Autoimmune Syndrome Type III, Polyglandular,Diabetes Mellitus, Addison Disease, Myxedema,Diabetes Mellitus, Addison's Disease, Myxedema,Multiple Endocrine Deficiency Syndrome, Type 2,Polyendocrine Autoimmune Syndrome, Type II,Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy, Autoimmune,Polyglandular Autoimmune Syndrome, Type 1,Polyglandular Autoimmune Syndrome, Type 2,Polyglandular Autoimmune Syndrome, Type 3,Polyglandular Autoimmune Syndrome, Type I,Polyglandular Deficiency Syndrome, Type 2,Polyglandular Type III Autoimmune Syndrome,Schmidt Syndrome,AIRE Deficiencies,Autoimmune Polyendocrinopathy,Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy,Deficiency, AIRE,Polyendocrinopathy Candidiasis Ectodermal Dystrophy, Autoimmune,Polyendocrinopathy, Autoimmune,Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, Autoimmune,Syndrome, Schmidt,Syndrome, Schmidt's