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1. The metabolism of (+/-)-p-hydroxy[14C]amphetamine has been studied in the rat, guinea-pig and man. 2. Most of the administered 14C was excreted in the urine within the first 24 h (64-92%), and was present mainly as free and conjugated p-hydroxy[14C]-amphetamine. In the female rat and female guinea-pig the conjugate was a glucuronide, but in man, who received a much smaller dose, the conjugate was a sulphate ester. A sex difference in conjugation was found in the rat, the female partly conjugating the drug but not the male. 3. Small quantities (1-6% of dose) of p-hydroxynorephedrine, a putative false neurotransmitter, were found in the urine of the three species. 4. Some oxidative degradation of the side chain of p-hydroxyamphetamine occurred in rat and guinea-pig since small amounts of p-hydroxybenzoic acid (1-3%) were detected in the urine.
P S Sever, and
L G Dring, and
R T Williams
November 1973,
Journal of pharmaceutical sciences,
P S Sever, and
L G Dring, and
R T Williams
October 1966,
Steroids,
P S Sever, and
L G Dring, and
R T Williams
January 1982,
Drug metabolism and disposition: the biological fate of chemicals,
P S Sever, and
L G Dring, and
R T Williams
January 1965,
Acta pharmacologica et toxicologica,
P S Sever, and
L G Dring, and
R T Williams
April 1987,
Endocrinologia japonica,
P S Sever, and
L G Dring, and
R T Williams
February 1978,
Journal of steroid biochemistry,
P S Sever, and
L G Dring, and
R T Williams
February 1971,
Biochimica et biophysica acta,
P S Sever, and
L G Dring, and
R T Williams
July 1987,
Journal of chromatography,
P S Sever, and
L G Dring, and
R T Williams
December 1982,
Scandinavian journal of immunology,
P S Sever, and
L G Dring, and
R T Williams
May 1979,
The Journal of pharmacy and pharmacology,
