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The PTEN/MMAC1 gene at 10q23.3, which has dual specific phosphatase activity, is a novel tumor suppressor gene candidate. Various kinds of tumors have mutations in this gene, including glioblastoma, endometrial carcinoma and prostate cancer. We examined 29 cases of primary non-Hodgkin's lymphoma (NHL) for mutations in the PTEN/MMAC1 gene. One case of diffuse large B cell lymphoma had an 11 bp deletion, but the remaining 28 cases showed no mutations in the genome. Two of these 28 cases showed missense mutations in the PTEN/MMAC1 transcripts, but no alterations in the genomic DNA. These mRNA missense variants are similar to PTEN/MMAC1 transcript aberrations which have been reported in patients with breast cancer. These findings suggest that alterations in the PTEN/MMAC1 gene play a role in the pathogenesis of NHL.
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
December 1999,
Molecular pathology : MP,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
August 2000,
European journal of haematology,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
January 2001,
Oncology reports,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
May 2003,
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
January 2001,
Brain tumor pathology,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
November 1998,
Clinical cancer research : an official journal of the American Association for Cancer Research,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
September 1998,
Oncogene,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
November 1998,
Gastroenterology,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
November 1999,
Journal of the National Cancer Institute,
Y Nakahara, and
H Nagai, and
T Kinoshita, and
T Uchida, and
S Hatano, and
T Murate, and
H Saito
March 2001,
Cancer genetics and cytogenetics,
