-transparent.png){kind=logo}
Cocaethylene, the metabolite of cocaine produced only in the presence of alcohol, produces a number of pharmacological, physiological, and behavioral effects. It also has a range of toxicological consequences, the most severe being lethality. Given that the assessments of cocaethylene lethality have been limited to mice, the present study assessed the lethality of cocaethylene in rats. Further, because of within-species sex differences with its parent compound, cocaine, cocaethylene lethality was also examined in both females and males. Specifically, female and male rats were injected IP with 75, 87, 100, 115, and 133 mg/kg cocaethylene and observed over a 24-h period. Deaths were dose dependent and occurred within 30 min for both females and males. For females, the LD50 was 96 mg/kg; for males, the LD50 was 70 mg/kg. The percentage of rats displaying severe effects (i.e., seizure and death) increased with dose across all postinjection times. Further, these effects occurred earlier as dose increased. Differences in the LD50 for rats and mice, as well as the greater sensitivity to cocaethylene in male rats, are discussed.
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
February 2021,
Behavioral neuroscience,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
February 1995,
Behavioral neuroscience,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
March 2011,
Physiology & behavior,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
July 1989,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
February 2022,
Behavioral neuroscience,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
May 1997,
Synapse (New York, N.Y.),
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
October 2020,
Behavioural pharmacology,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
January 2003,
Pharmacology, biochemistry, and behavior,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
February 2001,
Pharmacology, biochemistry, and behavior,
B F Sobel, and
A C Hutchinson, and
H F Diamond, and
S A Etkind, and
S D Ziervogel, and
C M Ferrari, and
A L Riley
June 1985,
European journal of pharmacology,
