BIOMAT Database Logo BIOMAT Database Logo

Elevated transforming growth factor-alpha levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. 1998

D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
Sections of Pulmonary and Critical Care Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98104-2092, USA.

The acute respiratory distress syndrome (ARDS) frequently results in a fibroproliferative response that precludes effective alveolar repair. Transforming growth factor-alpha (TGF-alpha), a potent epithelial and mesenchymal cell mitogen, may modulate the response to lung injury. In this study, we determined whether bronchoalveolar lavage fluid (BALF) concentrations of TGF-alpha are increased during the first 2 wk after the onset of ARDS and, if so, whether increased TGF-alpha levels in lavage fluid are associated with increased levels of procollagen peptide III (PCP III), a biological marker of fibroproliferation, and with increased fatality rates. We enrolled 74 consecutive patients with ARDS prospectively identified on admission to the intensive care unit of a tertiary care hospital, and 11 patients with chronic interstitial lung disease. Thirteen healthy volunteers served as control subjects. TGF-alpha concentrations were measured in BALF recovered on Days 3, 7, and 14 after the onset of ARDS (total of 130 lavage samples). TGF-alpha was detected in the lavage fluid of 90% of patients with ARDS (67 of 74), and in 100% of patients with idiopathic pulmonary fibrosis (IPF) (10 of 10), but in none of 13 normal volunteers. At each day tested, the median lavage TGF-alpha level of patients with ARDS was significantly higher than that of normals. The overall fatality rate was 45% (33 of 74 patients). In a univariate analysis, the median TGF-alpha levels in nonsurvivors were 1.5-fold higher at Day 7 (p = 0.06) and 1.8-fold higher at Day 14 (p = 0.048). The fatality rate was 4 times higher (CI 1.6, 17.5) for patients with both increased lavage TGF-alpha and PCP III concentrations at Day 7 than for patients with low TGF-alpha and PCP III values, indicating a synergistic relationship between TGF-alpha and PCP III. We conclude that increased levels of TGF-alpha in BALF are common in patients with ARDS and that lavage TGF-alpha is associated with a marker of the fibroproliferative response in sustained ARDS.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011347 Procollagen A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. Protocollagen,Procollagen Type M
D012128 Respiratory Distress Syndrome A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA. ARDS, Human,Acute Respiratory Distress Syndrome,Adult Respiratory Distress Syndrome,Pediatric Respiratory Distress Syndrome,Respiratory Distress Syndrome, Acute,Respiratory Distress Syndrome, Adult,Respiratory Distress Syndrome, Pediatric,Shock Lung,Distress Syndrome, Respiratory,Distress Syndromes, Respiratory,Human ARDS,Lung, Shock,Respiratory Distress Syndromes,Syndrome, Respiratory Distress
D001992 Bronchoalveolar Lavage Fluid Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung. Alveolar Lavage Fluid,Bronchial Lavage Fluid,Lung Lavage Fluid,Bronchial Alveolar Lavage Fluid,Lavage Fluid, Bronchial,Lavage Fluid, Lung,Pulmonary Lavage Fluid,Alveolar Lavage Fluids,Bronchial Lavage Fluids,Bronchoalveolar Lavage Fluids,Lavage Fluid, Alveolar,Lavage Fluid, Bronchoalveolar,Lavage Fluid, Pulmonary,Lavage Fluids, Alveolar,Lavage Fluids, Bronchial,Lavage Fluids, Bronchoalveolar,Lavage Fluids, Lung,Lavage Fluids, Pulmonary,Lung Lavage Fluids,Pulmonary Lavage Fluids
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
Keratinocyte growth factor and hepatocyte growth factor in bronchoalveolar lavage fluid in acute respiratory distress syndrome patients.
July 2000, Critical care medicine,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma.
October 1995, The Journal of rheumatology,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
Platelet-activating factor in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.
July 1992, Clinical and experimental pharmacology & physiology,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
Autoantibodies to lipids in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome.
October 2001, Critical care medicine,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
High concentrations of alpha-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome.
July 2004, Life sciences,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
Tumor necrosis factor levels in serum and bronchoalveolar lavage fluid of patients with the adult respiratory distress syndrome.
August 1991, The American review of respiratory disease,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
[Diagnosis of acute respiratory distress syndrome: analysis of bronchoalveolar lavage fluid].
December 1995, Nihon Kyobu Shikkan Gakkai zasshi,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
[Defensin in plasma and in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome].
December 1996, Nihon Kyobu Shikkan Gakkai zasshi,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation.
March 2007, Critical care medicine,
D K Madtes, and G Rubenfeld, and L D Klima, and J A Milberg, and K P Steinberg, and T R Martin, and G Raghu, and L D Hudson, and J G Clark
7S collagen in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.
April 1992, Chest,
Copied contents to your clipboard!