-transparent.png){kind=logo}
The present study was conducted to test the hypothesis that central corticotropin-releasing factor (CRF) systems mediate the changes in the dynamics of brain noradrenergic and serotonergic systems induced by electric footshock stress. Serum corticosterone concentrations were determined fluorometrically and brain monoamine contents (noradrenaline, serotonin and their metabolites) in five brain regions in rats were measured by high-performance liquid chromatography with electrochemical detection 10 and 40 min after exposure to electric footshock stress for 1 hour. Intracerebroventricular administration of a CRF antagonist, alpha-helical CRF (100 micrograms), had no effect on serum corticosterone concentrations in either normal or stressed animals. However, electric footshock stress-induced increases in noradrenaline turnover were significantly reduced by the administration of alpha-helical CRF9-41, in the amygdala and septum at both time points after exposure to electric footshock stress. In contrast, electric footshock stress-induced increases in serotonin turnover in all of the brain regions were further elevated by the administration of alpha-helical CRF 9-41, in almost all of the brain regions examined. These results suggest that central CRF neuronal systems are involved in mediating the electric footshock stress-induced changes in the dynamics of brain noradrenergic and serotonergic systems in rats.
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
April 1993,
Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
January 1982,
The Kurume medical journal,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
February 1982,
Pharmacology, biochemistry, and behavior,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
January 1985,
Japanese journal of pharmacology,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
January 1983,
The Kurume medical journal,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
May 1982,
Life sciences,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
November 1988,
Brain research,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
December 1985,
Life sciences,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
November 1993,
Brain research,
J Li, and
H Takeda, and
M Tsuji, and
L Liu, and
T Matsumiya
January 1983,
The Kurume medical journal,
