Biomaterial Database

Doppler sonography of breast tumours. 1998

S Delorme, and S Huber

German Cancer Research Centre, Department of Oncological Diagnosis and Therapy, Heidelberg, Germany.

BACKGROUND Doppler sonography has been used in breast tumours mainly for differential diagnostic purposes. Since angiogenesis appears to be related to the patient's prognosis, Doppler sonography may also have prognostic implications. RESULTS CW Doppler was initially used, but is now obsolete. Contemporary studies are carried out using colour Doppler. Quantification of colour Doppler is not available on ultrasound platforms, but has been developed for off-line analysis by several investigators. Vascular density and flow velocities are found to be higher in malignant than in benign tumours. However, in some malignant lesions, flow may be undetectable. Though the actual role of the method in differential diagnosis is still controversial, it may improve diagnostic confidence when performed by an experienced examiner. CONCLUSIONS Future fields of application currently being explored include monitoring of preoperative chemotherapy and prognostic assessment. Developments in the field of contrast media and scanner technology may further improve the quantitative estimation of tumour blood flow.

UI	MeSH Term	Description	Entries
D009389	Neovascularization, Pathologic	A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.	Angiogenesis, Pathologic,Angiogenesis, Pathological,Neovascularization, Pathological,Pathologic Angiogenesis,Pathologic Neovascularization,Pathological Angiogenesis,Pathological Neovascularization
D001943	Breast Neoplasms	Tumors or cancer of the human BREAST.	Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D018608	Ultrasonography, Doppler	Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)	Doppler Ultrasonography,Doppler Ultrasound,Doppler Ultrasound Imaging,Doppler Ultrasound Imagings,Doppler Ultrasounds,Imaging, Doppler Ultrasound,Imagings, Doppler Ultrasound,Ultrasound Imaging, Doppler,Ultrasound Imagings, Doppler,Ultrasound, Doppler,Ultrasounds, Doppler