-transparent.png){kind=logo}
OBJECTIVE Our purpose was to compare the effects of agents stimulating particulate and soluble guanylate cyclase with spontaneous rat uterine contractions at midgestation and term. METHODS Uterine rings from midgestation (day 13) and term nonlaboring (day 22) rats were positioned in organ chambers for isometric force recording. Rings were treated with increasing concentrations of atrial natriuretic peptide, permeable analogs of cyclic guanosine monophosphate, and diethylamine/nitric oxide. RESULTS Atrial natriuretic peptide was more effective in inhibition of uterine contractions than diethylamine/nitric oxide. The 50% inhibitory concentrations were -7.4 +/- 0.12 and -7.38 +/- 0.11 for atrial natriuretic peptide and -5.68 +/- 0.09 and -4.23 +/- 0.12 for diethylamine/nitric oxide at midgestation and term, respectively. Pretreatment of uterine rings with atrial natriuretic peptide significantly attenuated inhibition of spontaneous contractions by diethylamine/nitric oxide at midgestation. CONCLUSIONS Uterine spontaneous contractions are influenced by both soluble and particulate guanylate cyclase; the former, but not latter, is gestational age dependent.
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
January 1983,
Molecular and cellular biochemistry,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
January 1981,
Advances in cyclic nucleotide research,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
July 2001,
American journal of obstetrics and gynecology,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
December 2006,
Current opinion in structural biology,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
January 1991,
Biochemical and biophysical research communications,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
January 1993,
Experimental eye research,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
November 1996,
The American journal of physiology,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
January 2009,
Handbook of experimental pharmacology,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
November 2015,
European journal of pharmacology,
A S Syal, and
Y P Vedernikov, and
K Chwalisz, and
G R Saade, and
R E Garfield
January 2021,
Handbook of experimental pharmacology,
