-transparent.png){kind=logo}
Paraneoplastic neurological disorders represent remote effects of cancer without invasion of tumor cells into the nervous system. Limbic encephalitis is a distinct entity mostly associated with small-cell carcinoma of the lung. We present the cases of two teenage girls who were admitted with clinical symptoms typical for limbic encephalitis. In the course of the disease, they exhibited characteristic evolutionary changes of brain MRI abnormalities. Onset of neurological symptoms and type of underlying neoplasia were different in both patients. In one girl the initial workup led to the diagnosis of nodular sclerosing Hodgkin disease which so far had not caused any symptoms besides the described neurological abnormalities. A diagnostic brain biopsy showed inflammatory changes and excluded invasion of malignant cells into the central nervous system. The other patient had been diagnosed with a small cell carcinoma of the ovary several months before neurological and brain MRI abnormalities were observed. This is the first report in which clinical picture, evolution of MRI abnormalities, and--in one case--characteristic neuropathological changes are suggestive of paraneoplastic limbic encephalitis in two adolescent girls.
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
October 1997,
Lancet (London, England),
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
September 1997,
Der Pathologe,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
June 2004,
La Revue de medecine interne,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
January 2000,
Ryoikibetsu shokogun shirizu,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
February 1998,
Journal of neurology, neurosurgery, and psychiatry,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
March 2012,
Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
January 2009,
Psychosomatics,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
February 2005,
Clinical neurology and neurosurgery,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
January 2005,
European neurology,
T Rosenbaum, and
J Gärtner, and
D Körholz, and
G Janssen, and
D Schneider, and
V Engelbrecht, and
U Göbel, and
H G Lenard
January 2004,
Nihon rinsho. Japanese journal of clinical medicine,
