Inhibitory dysfunction in hyperactive boys. 1998

K Rubia, and J Oosterlaan, and J A Sergeant, and D Brandeis, and T v Leeuwen
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Maudsley Hospital, London, UK. k.rubia@iop.bpmf.iop.ac

Recent evidence suggests that the main deficit in childhood hyperactivity is in frontal lobe-mediated self-regulative functions such as inhibitory control. Hyperactives have consistently been shown to perform poorly on the stop task, which is a laboratory measurement of inhibitory control. This study was aimed at extending knowledge about inhibitory processes involved in the hyperactive's performance on this task. For this purpose, the performance of 11 pervasive hyperactives was compared to the performance of normal children on two stop tasks which differed from each other in the contingency of timing of the stop signal. In Stop1 stop signals were internally related, i.e. presented at time intervals after onset of the response stimulus, whereas in Stop2 stop signals were externally related, i.e. presented at time intervals related to the subject's own go-process. Both tasks were modifications of the classical stop task in modality of the stop signal visual instead of auditory and in event rate, which was half-shortened. The aim of this study was: (a) to replicate the findings of deficient inhibitory functions in hyperactive children in the stop task in spite of modifications in modality and event rate; and (b) to elucidate (dis)similarities of stopping processes or of group differences in these stopping processes triggered by stop delays related either to external or to internal processes. Hyperactive children were less efficient than controls in inhibiting their motor response in both versions of the stop task. independent of whether the stop signals were externally or internally related. Furthermore, the go-process of the hyperactives was more variable and erratic in both tasks. Thus, the results strengthen the effectiveness of stop tasks in distinguishing hyperactive from normal children.

UI MeSH Term Description Entries
D007266 Inhibition, Psychological The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. Inhibition (Psychology),Inhibition, Psychology,Psychological Inhibition,Inhibitions (Psychology),Inhibitions, Psychological,Inhibitions, Psychology,Psychological Inhibitions,Psychology Inhibition,Psychology Inhibitions
D007389 Internal-External Control Personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behavior versus fate, luck, or external forces. (ERIC Thesaurus, 1996). Locus of Control,External-Internal Control,Sense of Control,Control Locus,Control, External-Internal,Controls, External-Internal,Controls, Internal-External,Internal-External Controls
D008297 Male Males
D009433 Neural Inhibition The function of opposing or restraining the excitation of neurons or their target excitable cells. Inhibition, Neural
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D011930 Reaction Time The time from the onset of a stimulus until a response is observed. Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005625 Frontal Lobe The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus. Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001288 Attention Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating. Focus of Attention,Selective Attention,Social Attention,Attention Focus,Attention, Selective,Attention, Social,Selective Attentions

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