-transparent.png){kind=logo}
Kaposi's sarcoma-associated herpesvirus or human herpesvirus type 8 (HHV-8) is present in all forms of Kaposi's sarcoma (KS) as well as in primary effusion lymphomas and some cases of Castleman's disease. In KS tissues, HHV-8 is present in endothelial and spindle cells. Current serologic tests suggest that HHV-8 is predominantly found in those at risk of KS and is not as widespread as most other human herpesviruses. HHV-8 encodes various proteins that may play a role in promotion of cellular growth, including cyclin- and G-coupled protein receptor homologues, and anti-apoptotic proteins, including Bcl-2, IL-6 (i.e., interleukin 6), and FLIP (i.e., FLICE inhibitory protein) homologues. In addition, HHV-8 encodes two macrophage inflammatory-like proteins with anti-human immunodeficiency virus and angiogenic potential.
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
January 1997,
IARC monographs on the evaluation of carcinogenic risks to humans,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
March 1998,
Infectious disease clinics of North America,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
September 1997,
Seminars in cutaneous medicine and surgery,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
June 1997,
Uirusu,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
December 2002,
Uirusu,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
July 1998,
The Journal of general virology,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
December 1997,
Journal of the National Cancer Institute,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
February 2006,
Infection,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
February 1998,
Journal of Korean medical science,
R A Weiss, and
D Whitby, and
S Talbot, and
P Kellam, and
C Boshoff
January 1998,
Oral oncology,
