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Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group of nonfamilial PD and other patients. By cleavase fragment length polymorphism (CFLP) analysis and direct sequencing of the full coding region of GDNF gene we found a novel GDNF sequence variant in 1 of 30 PD patients. The alteration does not change the predicted amino acid sequence and it was also found in 1 of 20 patients without PD, suggesting that it represents a polymorphism in the gene. No other sequence variations were found. We conclude therefore that mutations in the GDNF coding region are not commonly contributing to the pathogenesis of PD.
K Wartiovaara, and
M Hytönen, and
M Vuori, and
L Paulin, and
J Rinne, and
H Sariola
January 2003,
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K Wartiovaara, and
M Hytönen, and
M Vuori, and
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H Sariola
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K Wartiovaara, and
M Hytönen, and
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H Sariola
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K Wartiovaara, and
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K Wartiovaara, and
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K Wartiovaara, and
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K Wartiovaara, and
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April 2024,
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology,
K Wartiovaara, and
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M Vuori, and
L Paulin, and
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H Sariola
December 2007,
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K Wartiovaara, and
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J Rinne, and
H Sariola
April 2019,
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K Wartiovaara, and
M Hytönen, and
M Vuori, and
L Paulin, and
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H Sariola
March 2005,
Brain research. Molecular brain research,
