-transparent.png){kind=logo}
The gene therapy strategy using the hsv1-thymidine kinase gene (TK) and ganciclovir (GCV) injections that has been used for treating human glioblastomas has not been as effective as expected after the first animal experiments. A better understanding of the different steps involved in this treatment, like gene transfer, gene expression, and sensitivity of the recipient cells is needed. Therefore, we studied 7 human glioblastoma cell lines (U87, U118, U251, SNB19, SNB75, SF295, SF539) for their sensitivity to the TK/GCV system. We also studied their in vitro bystander effect and their in vitro transfectability using LipofectAMINE as a transfection enhancer. According to this in vitro analysis, most of the glioblastoma cell lines should be sensitive to the TK/GCV system, but there is a significant need for agents to increase transfection efficiency.
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
January 1996,
Anticancer research,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
April 1998,
Human gene therapy,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
February 2000,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
April 1970,
Journal of virology,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
January 2021,
PloS one,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
December 2023,
Drug development research,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
October 1998,
Apoptosis : an international journal on programmed cell death,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
August 1981,
Virology,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
May 1998,
Nuclear medicine and biology,
F G Sturtz, and
K Waddell, and
J Shulok, and
X Chen, and
H R Snodgrass, and
D Platika
February 1999,
Cancer research,
