Biomaterial Database

Effect of vehicles on yohimbine permeation across excised hairless mouse skin. 1998

V Carelli, and G Di Colo, and E Nannipieri, and M F Serafini

Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Italy.

Turchi et al. [Turchi, P., Canale, D., Ducci, M., Nannipieri, E., Serafini, M. F., Menchini Fabris, G.F. (1992). The transdermal route in the treatment of male sexual impotence: preliminary data on the use of yohimbine. Int. J. Impotence Res. 4, 45-50.] showed that the application on penile skin of an oil-in-water cream (cream I.G) containing yohimbine (YO) was successful in the treatment of male sexual impotence. The components of the cream were stearyl alcohol, isopropyl lanolate, white petrolatum, liquid petrolatum, sodium lauryl sulphate (NaLS), propylene glycol (PG) and water. In the present study, a number of creams were derived from the cream I.G by adding, eliminating or replacing one or more constituents, and the effects of such changes on YO permeation through excised hairless mouse skin were investigated. From the data emerged the possibility of improving YO permeation even through slight changes in I.G composition. The stratum corneum-vehicle interactions were investigated by analyzing samples of isolated hairless mouse stratum corneum by DSC.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008812	Mice, Hairless	Mutant strains of mice that produce little or no hair.	Hairless Mice,Mice, Inbred HRS,Mice, hr,Hairless Mouse,Mice, HRS,Mouse, HRS,Mouse, Inbred HRS,HRS Mice,HRS Mice, Inbred,HRS Mouse,HRS Mouse, Inbred,Inbred HRS Mice,Inbred HRS Mouse,Mouse, Hairless
D004655	Emulsions	Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.	Emulsion
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D015016	Yohimbine	A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.	Rauwolscine,Aphrodine Hydrochloride,Aphrodyne,Corynanthine,Corynanthine Tartrate,Pluriviron,Rauhimbine,Yocon,Yohimbin Spiegel,Yohimbine Houdé,Yohimbine Hydrochloride,Yohimex,Hydrochloride, Aphrodine,Hydrochloride, Yohimbine,Tartrate, Corynanthine
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus