BIOMAT Database Logo BIOMAT Database Logo

Biochemical effects induced by REM sleep deprivation in naive and in D-amphetamine treated rats. 1998

A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
Depto. de Ciencias de la Salud, UAM-Iztapalapa, México D.F.

The neurochemical dysfunction present in patients showing self-mutilating behavior (SMB) is not well understood. In animal models, rapid eye movement (REM) sleep deprivation enhances the SMB induced by the chronic administration of d-amphetamine. To understand the mechanism underlying these effects the levels of dopamine (DA), noradrenaline (NA) and serotonin (5-HT) were measured in REM sleep deprived only, and in REM sleep deprived and d-amphetamine treated rats. DA levels were elevated (31%) after REM sleep deprivation (48 h) in the neostriatum and the cerebral cortex (33%), while the levels of NA and 5-HT remained constant. A 6-day treatment with d-amphetamine (7.5 mg/kg; i.p.) failed to affect, in REM sleep deprived rats, DA, NA and 5-HT levels. It was also found that REM sleep deprivation had no effects on the d-amphetamine induced [3H]DA release from slices of the same regions. Our results suggests that dopaminergic mechanisms are involved in the effects of REM sleep deprivation on SMB.

UI MeSH Term Description Entries
D008297 Male Males
D009638 Norepinephrine Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic. Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D003913 Dextroamphetamine The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic. d-Amphetamine,Curban,Dexamfetamine,Dexamphetamine,Dexedrine,Dextro-Amphetamine Sulfate,DextroStat,Dextroamphetamine Sulfate,Oxydess,d-Amphetamine Sulfate,dextro-Amphetamine,Dextro Amphetamine Sulfate,Sulfate, Dextroamphetamine,d Amphetamine,d Amphetamine Sulfate,dextro Amphetamine
D004298 Dopamine One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D012652 Self Mutilation The act of injuring one's own body to the extent of cutting off or permanently destroying a limb or other essential part of a body. Autotomy Human,Self Mutilating Behavior,Autotomy Humans,Behavior, Self Mutilating,Mutilating Behavior, Self,Mutilation, Self,Self Mutilating Behaviors
D012701 Serotonin A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator. 5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine

Related Publications

A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
Role of corticosterone on sleep homeostasis induced by REM sleep deprivation in rats.
January 2013, PloS one,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
The behavioral effects of REM sleep deprivation in rats.
March 1970, Psychophysiology,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
REM sleep deprivation and exploration in rats.
April 1976, Psychological reports,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
Potentiation of metaphit-induced audiogenic seizures by REM sleep deprivation in rats.
August 1993, Physiology & behavior,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
Negative transfer abolished by REM sleep deprivation in rats.
January 1982, Physiology & behavior,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
REM sleep deprivation diminishes fear in rats.
April 1979, Physiology & behavior,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
Effects of REM sleep deprivation of ACTH-induced yawning.
January 1990, Pharmacology,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
REM sleep deprivation and exploration in young rats.
June 1976, Psychological reports,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
REM sleep deprivation and pain thresholds in rats.
December 1978, Perceptual and motor skills,
A Lara-Lemus, and R Drucker-Colín, and J Méndez-Franco, and M Palomero-Rivero, and M Pérez de la Mora
Sleep Deprivation & Amphetamine Induced Psychosis.
June 2022, Psychopharmacology bulletin,
Copied contents to your clipboard!