-transparent.png){kind=logo}
The antitumor activity of a novel 4'-thionucleoside, 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine (4'-thio-FAC), was evaluated. 4'-Thio-FAC inhibited the in vitro growth of various human cancer cell lines, particularly the growth of cell lines established from gastric and colorectal carcinomas, while its oxy-type congener 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosine (FAC) showed little or no activity against such solid cancer cell lines. 4'-Thio-FAC showed a remarkable antitumor effect against human tumors subcutaneously implanted into nude mice and was highly effective even by oral administration. 4'-Thio-FAC was less susceptible to deamination by cytidine deaminase than FAC and 2'-deoxy-2',2'-difluorocytidine (gemcitabine) and therefore is a promising drug candidate for cancer chemotherapy.
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
May 2005,
International journal of cancer,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
July 2009,
Cancer chemotherapy and pharmacology,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
February 2012,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
August 1983,
Cancer research,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
January 2000,
Nucleosides, nucleotides & nucleic acids,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
September 2014,
Journal of labelled compounds & radiopharmaceuticals,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
January 1990,
Journal of medicinal chemistry,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
December 1980,
Journal of medicinal chemistry,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
December 1987,
Journal of medicinal chemistry,
S Miura, and
Y Yoshimura, and
M Endo, and
H Machida, and
A Matsuda, and
M Tanaka, and
T Sasaki
January 2003,
Nuclear medicine and biology,
