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The study deals with a total of 72 patients with Plasma cell dyscrasias (PCD) selected on the basis of atypical plasmacytosis in the bone marrow aspirate and radiological evidence of osteolytic lesions. Males(48) outnumbered the females (24). Pathological fracture and paraplegia was the commonest presenting symptom encountered in 38 patients. Electrophoresis of serum for 'M' band and Immunoelectrophoretic analysis of the serum revealed IgG myeloma in 40 patients followed by, IgA myeloma(13), Light chain disease (12) and other variants in remaining seven cases. The urinary Bence Jones proteins were detected in a total of 34 cases and was frequently encountered with IgA myeloma (7 out of 13) compared with IgG myeloma (13 out of 40) when analysed in Disc electrophoresis. Kappa light chain was observed in 21 cases and lambda counterpart in nine cases without any clinical significance. One case of solitary myeloma terminated in characteristic multicentric multiple myelomatosis within a span of six months in the sequential follow up study. We recommend the triangular approach to diagnosis of paraproteinemia with a special emphasis on immunoelectrophoresis for typing multiple myeloma and allied disorders along with disc electrophoresis for the demonstration of urinary Bence Jones protein in the routine set up.
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
May 2018,
Bulletin of experimental biology and medicine,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
January 1963,
Lo sperimentale,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
November 1969,
Seikeigeka. Orthopedic surgery,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
May 1974,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
February 1973,
Minerva medica,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
August 1981,
Immunology,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
June 1964,
Cancer,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
January 1987,
Acta haematologica,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
January 1982,
Orvosi hetilap,
Y S Thakar, and
C Chande, and
S Pande, and
A G Dhanvijay, and
A V Shrikhande, and
A M Saoji
April 1974,
Journal of the National Cancer Institute,
