BIOMAT Database Logo BIOMAT Database Logo

Allogeneic bone marrow transplantation for low-grade lymphoma. 1998

K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Joint Lymphoma Working Committee of the International Bone Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA.

Advanced low-grade lymphomas are usually incurable with conventional-dose chemotherapy. It is uncertain whether cures are possible with high-dose therapy and bone marrow transplant from a human leukocyte antigen (HLA)-identical sibling. We sought to determine the outcome of HLA-identical sibling bone marrow transplants in advanced low-grade lymphoma in an observational study of 113 patients conducted at 50 centers participating in the International Bone Marrow Transplant Registry (IBMTR). The median patient age was 38 years (range, 15 to 61). Eighty percent had stage IV disease at the time of transplantation. The median number of prior chemotherapy regimens was two (range, 0 to 5). Thirty-eight percent had refractory disease and 29% a Karnofsky performance score (KPS) less than 80%. All patients underwent allogeneic bone marrow transplantation from a HLA-identical sibling donor. The conditioning regimen included total-body irradiation (TBI) in 82% of patients; cyclosporine was used for graft-versus-host disease prophylaxis in 74%. Survival, disease-free survival, recurrence rate, treatment-related mortality, and causes of death were determined. Three-year probabilities of recurrence, survival, and disease-free survival were 16% (95% confidence interval [CI], 9% to 27%), 49% (95% CI, 39% to 60%), and 49% (95% CI, 39% to 59%), respectively. Higher survival was associated with pretransplant KPS >/=90%, chemotherapy-sensitive disease, use of a TBI-containing conditioning regimen, and age less than 40 years. We conclude that high-dose therapy followed by transplantation from a HLA-identical sibling leads to prolonged survival in some patients with advanced low-grade lymphoma. Most mortality is treatment-related, and recurrences are rare.

UI MeSH Term Description Entries
D008224 Lymphoma, Follicular Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. Brill-Symmers Disease,Follicular Lymphoma,Lymphoma, Giant Follicular,Lymphoma, Nodular,Follicular Large-Cell Lymphoma,Follicular Lymphoma, Giant,Follicular Lymphoma, Grade 1,Follicular Lymphoma, Grade 2,Follicular Lymphoma, Grade 3,Follicular Mixed-Cell Lymphoma,Giant Follicular Lymphoma,Histiocytic Lymphoma, Nodular,Large Lymphoid Lymphoma, Nodular,Large-Cell Lymphoma, Follicular,Lymphocytic Lymphoma, Nodular, Poorly Differentiated,Lymphocytic Lymphoma, Nodular, Poorly-Differentiated,Lymphoma, Follicular Large-Cell,Lymphoma, Follicular, Grade 1,Lymphoma, Follicular, Grade 2,Lymphoma, Follicular, Grade 3,Lymphoma, Follicular, Mixed Cell,Lymphoma, Follicular, Mixed Lymphocytic-Histiocytic,Lymphoma, Follicular, Mixed Small and Large Lymphoid,Lymphoma, Follicular, Small and Large Cleaved Cell,Lymphoma, Follicular, Small and Large Cleaved-Cell,Lymphoma, Histiocytic, Nodular,Lymphoma, Large Cell, Follicular,Lymphoma, Large Lymphoid, Nodular,Lymphoma, Large-Cell, Follicular,Lymphoma, Lymphocytic, Nodular, Poorly Differentiated,Lymphoma, Lymphocytic, Nodular, Poorly-Differentiated,Lymphoma, Mixed-Cell, Follicular,Lymphoma, Nodular, Large Follicular Center Cell,Lymphoma, Nodular, Large Follicular Center-Cell,Lymphoma, Nodular, Mixed Lymphocytic Histiocytic,Lymphoma, Nodular, Mixed Lymphocytic-Histiocytic,Lymphoma, Nodular, Mixed Small and Large Cell,Lymphoma, Small Cleaved Cell, Follicular,Lymphoma, Small Cleaved-Cell, Follicular,Lymphoma, Small Follicular Center-Cell,Lymphoma, Small Lymphoid, Follicular,Mixed-Cell Lymphoma, Follicular,Nodular Large Follicular Center-Cell Lymphoma,Small Cleaved-Cell Lymphoma, Follicular,Small Follicular Center-Cell Lymphoma,Brill Symmers Disease,Disease, Brill-Symmers,Follicular Large Cell Lymphoma,Follicular Large-Cell Lymphomas,Follicular Lymphomas,Follicular Lymphomas, Giant,Follicular Mixed Cell Lymphoma,Follicular Mixed-Cell Lymphomas,Giant Follicular Lymphomas,Histiocytic Lymphomas, Nodular,Large Cell Lymphoma, Follicular,Large-Cell Lymphomas, Follicular,Lymphoma, Follicular Large Cell,Lymphoma, Follicular Mixed-Cell,Lymphoma, Nodular Histiocytic,Lymphoma, Small Follicular Center Cell,Lymphomas, Follicular,Lymphomas, Follicular Large-Cell,Lymphomas, Follicular Mixed-Cell,Lymphomas, Giant Follicular,Lymphomas, Nodular,Lymphomas, Nodular Histiocytic,Mixed Cell Lymphoma, Follicular,Mixed-Cell Lymphomas, Follicular,Nodular Histiocytic Lymphoma,Nodular Histiocytic Lymphomas,Nodular Large Follicular Center Cell Lymphoma,Nodular Lymphoma,Nodular Lymphomas,Small Cleaved Cell Lymphoma, Follicular,Small Follicular Center Cell Lymphoma
D008228 Lymphoma, Non-Hodgkin Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. Non-Hodgkin Lymphoma,Diffuse Mixed Small and Large Cell Lymphoma,Diffuse Mixed-Cell Lymphoma,Diffuse Small Cleaved-Cell Lymphoma,Diffuse Undifferentiated Lymphoma,Lymphatic Sarcoma,Lymphoma, Atypical Diffuse Small Lymphoid,Lymphoma, Diffuse,Lymphoma, Diffuse, Mixed Lymphocytic-Histiocytic,Lymphoma, High-Grade,Lymphoma, Intermediate-Grade,Lymphoma, Low-Grade,Lymphoma, Mixed,Lymphoma, Mixed Cell, Diffuse,Lymphoma, Mixed Lymphocytic-Histiocytic,Lymphoma, Mixed Small and Large Cell, Diffuse,Lymphoma, Mixed-Cell,Lymphoma, Mixed-Cell, Diffuse,Lymphoma, Non-Hodgkin's,Lymphoma, Non-Hodgkin, Familial,Lymphoma, Non-Hodgkins,Lymphoma, Nonhodgkin's,Lymphoma, Nonhodgkins,Lymphoma, Pleomorphic,Lymphoma, Small Cleaved Cell, Diffuse,Lymphoma, Small Cleaved-Cell, Diffuse,Lymphoma, Small Non-Cleaved-Cell,Lymphoma, Small Noncleaved-Cell,Lymphoma, Small and Large Cleaved-Cell, Diffuse,Lymphoma, Undifferentiated,Lymphoma, Undifferentiated, Diffuse,Lymphosarcoma,Mixed Small and Large Cell Lymphoma, Diffuse,Mixed-Cell Lymphoma,Mixed-Cell Lymphoma, Diffuse,Non-Hodgkin's Lymphoma,Reticulosarcoma,Reticulum Cell Sarcoma,Reticulum-Cell Sarcoma,Sarcoma, Lymphatic,Sarcoma, Reticulum-Cell,Small Cleaved-Cell Lymphoma, Diffuse,Small Non-Cleaved-Cell Lymphoma,Small Noncleaved-Cell Lymphoma,Undifferentiated Lymphoma,Diffuse Lymphoma,Diffuse Lymphomas,Diffuse Mixed Cell Lymphoma,Diffuse Mixed-Cell Lymphomas,Diffuse Small Cleaved Cell Lymphoma,Diffuse Undifferentiated Lymphomas,High-Grade Lymphoma,High-Grade Lymphomas,Intermediate-Grade Lymphoma,Intermediate-Grade Lymphomas,Low-Grade Lymphoma,Low-Grade Lymphomas,Lymphatic Sarcomas,Lymphocytic-Histiocytic Lymphoma, Mixed,Lymphocytic-Histiocytic Lymphomas, Mixed,Lymphoma, Diffuse Mixed-Cell,Lymphoma, Diffuse Undifferentiated,Lymphoma, High Grade,Lymphoma, Intermediate Grade,Lymphoma, Low Grade,Lymphoma, Mixed Cell,Lymphoma, Mixed Lymphocytic Histiocytic,Lymphoma, Non Hodgkin,Lymphoma, Non Hodgkin's,Lymphoma, Non Hodgkins,Lymphoma, Nonhodgkin,Lymphoma, Small Non Cleaved Cell,Lymphoma, Small Noncleaved Cell,Lymphosarcomas,Mixed Cell Lymphoma,Mixed Cell Lymphoma, Diffuse,Mixed Lymphocytic-Histiocytic Lymphoma,Mixed Lymphocytic-Histiocytic Lymphomas,Mixed Lymphoma,Mixed Lymphomas,Mixed-Cell Lymphomas,Non Hodgkin Lymphoma,Non Hodgkin's Lymphoma,Non-Cleaved-Cell Lymphoma, Small,Non-Hodgkins Lymphoma,Noncleaved-Cell Lymphoma, Small,Nonhodgkin's Lymphoma,Nonhodgkins Lymphoma,Pleomorphic Lymphoma,Pleomorphic Lymphomas,Reticulosarcomas,Reticulum Cell Sarcomas,Reticulum-Cell Sarcomas,Sarcoma, Reticulum Cell,Small Cleaved Cell Lymphoma, Diffuse,Small Non Cleaved Cell Lymphoma,Small Non-Cleaved-Cell Lymphomas,Small Noncleaved Cell Lymphoma,Small Noncleaved-Cell Lymphomas,Undifferentiated Lymphoma, Diffuse,Undifferentiated Lymphomas
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D009679 Nuclear Family A family composed of spouses and their children. Daughters,Sons,Daughter,Families, Nuclear,Family, Nuclear,Nuclear Families,Son
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D012042 Registries The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers. Parish Registers,Population Register,Parish Register,Population Registers,Register, Parish,Register, Population,Registers, Parish,Registers, Population,Registry
D002423 Cause of Death Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint. Causes of Death,Death Cause,Death Causes
D005260 Female Females

Related Publications

K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Allogeneic bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia.
March 2000, Bone marrow transplantation,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Allogeneic bone marrow transplantation in patients with sensitive low-grade lymphoma or mantle cell lymphoma.
January 2001, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Allogeneic bone marrow transplantation for lymphoma.
March 2000, Blood reviews,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Allogeneic versus autologous bone marrow transplantation for refractory and recurrent low-grade non-Hodgkin's lymphoma.
November 1997, Blood,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Allogeneic bone marrow transplantation for refractory and recurrent low-grade lymphoma: the case for aggressive management.
May 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Bone marrow transplantation in low-grade non-Hodgkin's lymphoma.
April 1995, Leukemia & lymphoma,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia.
April 1999, Seminars in hematology,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Autologous bone marrow transplantation for non-transformed low-grade non-Hodgkin's lymphoma.
September 1995, Bone marrow transplantation,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Allogeneic bone marrow transplantation with T-cell-depleted marrow grafts for patients with poor-risk relapsed low-grade non-Hodgkin's lymphoma.
January 1998, British journal of haematology,
K van Besien, and K A Sobocinski, and P A Rowlings, and S C Murphy, and J O Armitage, and M R Bishop, and O K Chaekal, and R P Gale, and J P Klein, and H M Lazarus, and P L McCarthy, and J M Raemaekers, and J Reiffers, and G L Phillips, and A V Schattenberg, and L F Verdonck, and J M Vose, and M M Horowitz
Allogeneic bone marrow transplantation for refractory mantle cell lymphoma.
October 2000, Annals of hematology,
Copied contents to your clipboard!