Biomaterial Database

Organochlorine pesticide-induced oxidative stress and immune suppression in rats. 1998

B C Koner, and B D Banerjee, and A Ray

Department of Biochemistry and Pharmacology, University College of Medical Sciences and G.T.B. Hospital, University of Delhi, India.

Effects of subchronic DDT and lindane exposure were evaluated on lipid peroxidation, antioxidant mechanisms and humoral immune response in rats. Oral administration of DDT, (100 and 200 ppm) and lindane (40 and 80 ppm) dose dependently increased thiobarbituric acid reactive substance (TBARS) levels in serum after 8 wk of treatment. Superoxide dismutase (SOD) activity in red blood cells (RBC) was also dose dependently increased by these compounds. In addition, such DDT or lindane exposure markedly suppressed the humoral immune response as assessed by anti-sheep RBC antibody titres. Simultaneous treatment with ascorbic acid (100 mg/kg) markedly attenuated the effects of DDT and lindane on (a) lipid peroxidation, (b) SOD activity and (c) humoral immune suppression. These results indicate the possible involvement of free radicals in organochlorine-induced immunotoxicity.

UI	MeSH Term	Description	Entries
D007306	Insecticides	Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.	Insecticide
D008297	Male		Males
D003634	DDT	A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)	1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane,4,4'-DDT,4,4'-Dichlorodiphenyltrichloroethane,Benzochloryl,Chlorophenothane,TbisC-ethane,p',p'-DDT,4,4' DDT,4,4' Dichlorodiphenyltrichloroethane,TbisC ethane
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D001556	Hexachlorocyclohexane	Any of several polyhalogenated organic compounds consisting of a six-carbon ring with one chlorine and one hydrogen attached to each carbon.	Benzene Hexachloride,Lindane,gamma-Benzene Hexachloride,BHC Insecticide,Delitex,Epsilon-hexachlorocyclohexane,Eta-hexachlorocyclohexane,Gamma-666,Gammexane,Hexachlorane,Jacutin,Kwell,PMS-Lindane,Scabecid,Scabene,Scabisan,Tetocid,Zeta-hexachlorocyclohexane,gamma-HCH,gamma-Hexachlorocyclohexane,Epsilon hexachlorocyclohexane,Eta hexachlorocyclohexane,Gamma 666,Hexachloride, Benzene,Hexachloride, gamma-Benzene,Insecticide, BHC,PMS Lindane,Zeta hexachlorocyclohexane,gamma Benzene Hexachloride,gamma HCH,gamma Hexachlorocyclohexane
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018384	Oxidative Stress	A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).	Anti-oxidative Stress,Antioxidative Stress,DNA Oxidative Damage,Nitro-Oxidative Stress,Oxidative Cleavage,Oxidative DNA Damage,Oxidative Damage,Oxidative Injury,Oxidative Nitrative Stress,Oxidative Stress Injury,Oxidative and Nitrosative Stress,Stress, Oxidative,Anti oxidative Stress,Anti-oxidative Stresses,Antioxidative Stresses,Cleavage, Oxidative,DNA Damage, Oxidative,DNA Oxidative Damages,Damage, DNA Oxidative,Damage, Oxidative,Damage, Oxidative DNA,Injury, Oxidative,Injury, Oxidative Stress,Nitrative Stress, Oxidative,Nitro Oxidative Stress,Nitro-Oxidative Stresses,Oxidative Cleavages,Oxidative DNA Damages,Oxidative Damage, DNA,Oxidative Damages,Oxidative Injuries,Oxidative Nitrative Stresses,Oxidative Stress Injuries,Oxidative Stresses,Stress Injury, Oxidative,Stress, Anti-oxidative,Stress, Antioxidative,Stress, Nitro-Oxidative,Stress, Oxidative Nitrative,Stresses, Nitro-Oxidative