Effect of oleoyl-estrone administration on corticosterone binding to tissues of lean and obese Zucker rats. 1998

M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
Centre d'Investigació Laboratoris S.A.L.V.A.T., S.A., Esplugues de Llobregat, Universitat de Barcelona, Spain.

A group of female Zucker lean and obese rats was treated with 3.5 micromol/day kg of oleoyl-estrone in liposomes (OE) injected i.v. continuously for 14 days with inserted osmotic minipumps. Samples of liver were extracted on days 0, 3, 6, 10 and 14 and the expression of corticosterone-binding globulin (CBG) was determined by Northern blot. On the same dates, the total binding capacity of plasma, liver, periovaric white adipose tissue (WAT) and subcutaneous WAT was also determined using tritium-labelled corticosterone. Treatment with OE resulted in diminished CBG gene expression in the liver, this being more marked in the obese rats. Basal (time 0) corticosterone binding was higher in the plasma, liver and WAT of lean rats. Treatment with OE resulted in a gradual and general loss of binding capacity in the plasma and all tissues studied, for lean and obese rats alike. Since CBG decreases may result in enhanced glucocorticoid availability (and effects), the global decrease in corticosterone binding observed can be interpreted as a counteractive response to the energy imbalance elicited by OE.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008081 Liposomes Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins. Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D009829 Oleic Acids A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon. Octadecenoic Acids,Acids, Octadecenoic,Acids, Oleic
D010053 Ovary The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE. Ovaries
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D011924 Rats, Zucker Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene. Zucker Rat,Zucker Rats,Rat, Zucker
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D003345 Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Related Publications

M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
January 1998, Obesity research,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
August 2001, European journal of nutrition,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
May 2002, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
April 2003, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
September 1997, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
January 2011, Nutrition (Burbank, Los Angeles County, Calif.),
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
August 2006, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
June 1989, Metabolism: clinical and experimental,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
December 2004, Diabetes, nutrition & metabolism,
M M Grasa, and C Cabot, and C Adán, and D Sanchis, and F Balada, and J Estruch, and J A Fernández-López, and X Remesar, and M Alemany
July 1984, The Journal of nutrition,
Copied contents to your clipboard!