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The relationships between substrate utilization and renal work were investigated in an isolated, perfused dog kidney preparation: substrate utilization included free-fatty acid (FFA), glucose, and oxygen, whereas work was assessed by measuring TNa+. The magnitude of TNa+ was varied by altering glomerular filtration rate as a consequence of changing renal blood flow. As the rate of renal blood flow was reduced, both Qo2, and QFFA decreased while Qglucose increased. The reduction in QFFA and Qo2 paralleled the decrease in TNa+. An inverse relationship was noted between QFFA and Qglucose in all experiments. The results suggest that FFA and perhaps glucose may serve as a significant substrate for providing energy for TNA+ in the kidney. Further, since QFFA and Qglucose are inversely related to each other, glucose may substitute for FFA as an energy source at times when QFFA is reduced.
M Tark, and
H M Randall, and
T L Hoffer
January 1963,
UR [reports]. U.S. Atomic Energy Commission,
M Tark, and
H M Randall, and
T L Hoffer
November 1968,
The British journal of surgery,
M Tark, and
H M Randall, and
T L Hoffer
January 1967,
Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere,
M Tark, and
H M Randall, and
T L Hoffer
June 1972,
The Biochemical journal,
M Tark, and
H M Randall, and
T L Hoffer
August 1983,
Life sciences,
M Tark, and
H M Randall, and
T L Hoffer
May 1978,
The American journal of physiology,
M Tark, and
H M Randall, and
T L Hoffer
March 1956,
The Journal of biological chemistry,
M Tark, and
H M Randall, and
T L Hoffer
February 1956,
Archives of biochemistry and biophysics,
M Tark, and
H M Randall, and
T L Hoffer
September 1975,
Xenobiotica; the fate of foreign compounds in biological systems,
M Tark, and
H M Randall, and
T L Hoffer
April 1944,
The Journal of physiology,
