BIOMAT Database Logo BIOMAT Database Logo

Acanthamoeba meningoencephalitis following autologous peripheral stem cell transplantation. 1998

J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Jean Marie Colbert Bone Marrow Transplant Center, University of Connecticut School of Medicine, Farmington 06062, USA.

Amoebic meningoencephalitis is an unusual complication of bone marrow transplantation. We report a case of Acanthamoeba meningoencephalitis in a patient with non-Hodgkin's lymphoma after autologous stem cell transplantation. Leg weakness, fever and urinary retention developed 69 days following transplantation. The patient then developed fever, generalized tonic clonic seizure, rapid deterioration of mental functions and hypercapneic respiratory failure. Magnetic resonance imaging demonstrated a ring enhancing lesion at the level of the thoracic spines 11 and 12. Examination of the cerebrospinal fluid revealed pleocytosis. Despite empiric therapy with broad-spectrum antimicrobial agents, the patient's condition worsened and she died 11 days following admission. Autopsy findings revealed a subacute meningoencephalitis secondary to Acanthamoeba culbertsoni.

UI MeSH Term Description Entries
D008590 Meningoencephalitis An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions. Cerebromeningitis,Encephalomeningitis,Cerebromeningitides,Encephalomeningitides,Meningoencephalitides
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009894 Opportunistic Infections An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression. Infection, Opportunistic,Infections, Opportunistic,Opportunistic Infection
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000048 Acanthamoeba A genus of free-living soil amoebae that produces no flagellate stage. Its organisms are pathogens for several infections in humans and have been found in the eye, bone, brain, and respiratory tract. Acanthamoebas
D000562 Amebiasis Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur. Abscess, Amebic,Acanthamebiasis,Ameboma,Amoebiasis,Iodamoebiasis,Acanthamoeba Infection,Balamuthia Infection,Abscesses, Amebic,Acanthamebiases,Acanthamoeba Infections,Amebiases,Amebic Abscess,Amebic Abscesses,Amoebiases,Balamuthia Infections,Infection, Acanthamoeba,Infection, Balamuthia,Iodamoebiases
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014182 Transplantation, Autologous Transplantation of an individual's own tissue from one site to another site. Autografting,Autologous Transplantation,Autotransplantation,Autograftings,Autologous Transplantations,Autotransplantations,Transplantations, Autologous
D016393 Lymphoma, B-Cell A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. B-Cell Lymphoma,B Cell Lymphoma,B-Cell Lymphomas,Lymphoma, B Cell,Lymphomas, B-Cell

Related Publications

J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Unexpected postmortem diagnosis of Acanthamoeba meningoencephalitis following allogeneic peripheral blood stem cell transplantation.
July 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Think outside the box: Acanthamoeba encephalitis following autologous haematopoietic stem cell transplantation.
December 2016, British journal of haematology,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Autoreactive antibodies following autologous peripheral blood stem cell transplantation.
October 1998, Bone marrow transplantation,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
[Autologous peripheral stem cell transplantation].
November 1988, Gan to kagaku ryoho. Cancer & chemotherapy,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Autologous peripheral stem-cell transplantation.
August 1995, Health technology assessment,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Acanthamoeba castellani encephalitis following partially mismatched related donor peripheral stem cell transplantation.
December 2003, Transplant infectious disease : an official journal of the Transplantation Society,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Eosinophilic pustular folliculitis following autologous peripheral blood stem-cell transplantation.
January 2004, The Journal of dermatology,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Neuroleptic malignant syndrome following autologous peripheral blood stem cell transplantation.
February 1998, Bone marrow transplantation,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
Streptococcus viridans bacteremia following autologous peripheral blood stem cell transplantation.
March 1998, Bone marrow transplantation,
J M Feingold, and J Abraham, and S Bilgrami, and N Ngo, and G S Visvesara, and R L Edwards, and P J Tutschka
[Human herpesvirus-6 pneumonitis following autologous peripheral blood stem cell transplantation].
January 2018, [Rinsho ketsueki] The Japanese journal of clinical hematology,
Copied contents to your clipboard!