Alkylation of polyguanylic acid at the 2-amino group and phosphate by the potent mutagen (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
1976
M Koreeda, and
P D Moore, and
H Yagi, and
H J Yeh, and
D M Jerina
UI
MeSH Term
Description
Entries
D009153
Mutagens
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D011068
Poly G
A group of guanine ribonucleotides in which the phosphate residues of each guanine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
A group of 13 or more ribonucleotides in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
D000478
Alkylation
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
Alkylations
D001580
Benzopyrenes
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Benzpyrene
D001665
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.