Alkylation of polyguanylic acid at the 2-amino group and phosphate by the potent mutagen (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. 1976

M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina

UI MeSH Term Description Entries
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D011068 Poly G A group of guanine ribonucleotides in which the phosphate residues of each guanine ribonucleotide act as bridges in forming diester linkages between the ribose moieties. Guanine Polynucleotides,Polyguanylic Acids,Acids, Polyguanylic,Polynucleotides, Guanine
D011131 Polyribonucleotides A group of 13 or more ribonucleotides in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
D000478 Alkylation The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group. Alkylations
D001580 Benzopyrenes A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it. Benzpyrene
D001665 Binding Sites The parts of a macromolecule that directly participate in its specific combination with another molecule. Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining

Related Publications

M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina
September 1976, International journal of cancer,
M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina
June 1998, Chemical research in toxicology,
M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina
March 1980, Carcinogenesis,
M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina
August 1976, Proceedings of the National Academy of Sciences of the United States of America,
M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina
July 1983, Journal of pharmaceutical sciences,
M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina
November 1978, Proceedings of the National Academy of Sciences of the United States of America,
M Koreeda, and P D Moore, and H Yagi, and H J Yeh, and D M Jerina
July 1992, Toxicology and applied pharmacology,
Copied contents to your clipboard!