Biomaterial Database

Motor responsiveness of proximal and distal human colonic muscle layers to carbachol and neurotensin. 1998

M A Maselli, and A L Piepoli, and G Riezzo, and F Pezzolla

Department of Surgery, Scientific Institute of Gastroenterology, Castellana Grotte, Bari, Italy.

A regional heterogeneity of the responsiveness to neurohumoral agents has been demonstrated in proximal and distal colon. The aim of this study was to compare the motor responsiveness of circular and longitudinal muscles from ascending and sigmoid colon to carbachol and neurotensin. Ascending colon circular muscle was more sensitive to carbachol than sigmoid colon circular muscle (P < 0.05). Moreover, the potency for the carbachol-stimulated contraction was greater in ascending colon circular than longitudinal muscle (P < 0.05). The potency for carbachol and neurotensin stimulations was similar in longitudinal and circular muscles of both sections, respectively. However, the ascending colon circular muscle had a greater potency to neurotensin than longitudinal muscle (P < 0.03). Longitudinal muscle was more sensitive to the effects of neurotensin in sigmoid than ascending colon (P < 0.01). On a molar basis, neurotensin was approximately fivefold more potent than carbachol in producing similar contractions. These data suggest that these agents stimulate human colon smooth muscle according to region and type of muscle layer.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D009496	Neurotensin	A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.
D002217	Carbachol	A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	Carbamylcholine,Carbacholine,Carbamann,Carbamoylcholine,Carbastat,Carbocholine,Carboptic,Doryl,Isopto Carbachol,Jestryl,Miostat,Carbachol, Isopto
D003106	Colon	The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.	Appendix Epiploica,Taenia Coli,Omental Appendices,Omental Appendix,Appendices, Omental,Appendix, Omental
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man