Acute pancreatitis in childhood is a rare condition but should still be considered in all children presenting with abdominal pain. A complete history and physical exam with emphasis on recent trauma, infection, chronic diseases, and current medications should be obtained. Numerous and varied drugs have been implicated in the development of pancreatitis. Since many of these drugs are among most physicians' armamentarium, it is important to establish their causal relationship to pancreatitis. Careful appraisal of the drugs associated with acute pancreatitis and of the primary disease for which they were prescribed may, in the long run, provide new avenues of thought as to the pathogenesis of drug-induced pancreatitis.