Biomaterial Database

Yolk sac tumor of the placenta in Wiedemann-Beckwith syndrome. 1998

R Drut, and M Mortera, and R M Drut

Department of Pathology, Hospital de Niños "Superiora Sor María Ludovica," 14 No. 1631, 1900 La Plata, Argentina.

The present report describes an example of multifocal (two) yolk sac tumor (YST) with mesenchyme-like and enteroid patterns found in the placenta (730 g) of a newborn (4200 g) with Wiedemann-Beckwith syndrome (WBS) phenotype (macroglossia, omphalocele, hemihypertrophy, cardiomegaly, hypoglycemia). YST has not been previously reported to develop in the placenta. This case expands further the spectrum of alterations found in the placenta in the WBS and fits in the list of tumors related to WBS. ¿KW¿

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D010920	Placenta	A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).	Placentoma, Normal,Placentome,Placentas,Placentomes
D010922	Placenta Diseases	Pathological processes or abnormal functions of the PLACENTA.	Placenta Disorders,Placental Diseases,Disease, Placenta,Disease, Placental,Diseases, Placenta,Diseases, Placental,Disorder, Placenta,Disorders, Placenta,Placenta Disease,Placenta Disorder,Placental Disease
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001506	Beckwith-Wiedemann Syndrome	A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities.	Wiedemann Syndrome,Wiedemann-Beckwith Syndrome,Wiedemann-Beckwith Syndrome (WBS),EMG Syndrome,Exomphalos-Macroglossia-Gigantism Syndrome,Beckwith Wiedemann Syndrome,EMG Syndromes,Exomphalos Macroglossia Gigantism Syndrome,Exomphalos-Macroglossia-Gigantism Syndromes,Syndrome, Beckwith-Wiedemann,Syndrome, EMG,Syndrome, Exomphalos-Macroglossia-Gigantism,Syndrome, Wiedemann,Syndrome, Wiedemann-Beckwith,Syndrome, Wiedemann-Beckwith (WBS),Wiedemann Beckwith Syndrome,Wiedemann Beckwith Syndrome (WBS),Wiedemann Syndromes,Wiedemann-Beckwith Syndromes (WBS)
D017809	Fatal Outcome	Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.	Fatal Outcomes,Outcome, Fatal,Outcomes, Fatal
D018240	Endodermal Sinus Tumor	An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)	Yolk Sac Tumor,Endodermal Sinus Tumors,Tumor, Endodermal Sinus,Tumor, Yolk Sac,Tumors, Endodermal Sinus,Tumors, Yolk Sac,Yolk Sac Tumors