BIOMAT Database Logo BIOMAT Database Logo

The relationship between plasma homocysteine and amino acid concentrations in patients with end-stage renal disease. 1998

S Y Hong, and D H Yang, and S K Chang
Department of Internal Medicine, Soonchunhyang University, Chunan City, Korea.

OBJECTIVE Observe the relationship between homocysteine and other amino acids in patients with end-stage renal disease (ESRD). METHODS A cross-sectional study of amino acids and homocysteine and comparison of the correlations between ESRD and control group. METHODS Nephrology unit of Soonchunhyang University hospital in Chunan, Korea. METHODS Forty-five ESRD patients and 30 control volunteers. METHODS Plasma amino acids and homocysteine. RESULTS Concentrations of asparate, proline and cysteine were higher and serine, tyrosine, valine, isoleuline, leucine, and lysine levels were lower in the ESRD group than in control group. The branched chain amino acids (BCAAs) and essential amino acid were lower in the ESRD group than in the control group, but there was no difference in non-essential amino acid and total amino acid between the two groups. The mean plasma total homocysteine concentrations were 6 +/- 1 mmol/L in the control group and 14 +/- 4 mmol/L in the ESRD group (P < .001). In the ESRD group, homocysteine concentrations showed a direct correlation with the concentration of histidine (R2: .403, P < .001), valine (R2: .324, P < .01), leucine (R2: .400, P < .01), isoleucine (R2: .351, P < .005), cysteine (R2: .287, P < .001), methionine (R2: .256, P < .01), BCAA (R2: .50, P < .01), and essential amino acid (R2: .416, P < .01). In the control group, no correlation between the homocysteine and amino acid concentrations was found. CONCLUSIONS Contrary to the control group, the homocysteine concentrations showed a direct correlation with the concentration of valine, leucine, isoleucine, methionine, and histidine levels in the ESRD group. Altered essential amino acid metabolism, specifically BCAAs and histidine, influence hyperhomocysteinemia in ESRD. Further study is needed to confirm this theory.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D008715 Methionine A sulfur-containing essential L-amino acid that is important in many body functions. L-Methionine,Liquimeth,Methionine, L-Isomer,Pedameth,L-Isomer Methionine,Methionine, L Isomer
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D003545 Cysteine A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D005260 Female Females
D006639 Histidine An essential amino acid that is required for the production of HISTAMINE. Histidine, L-isomer,L-Histidine,Histidine, L isomer,L-isomer Histidine
D006710 Homocysteine A thiol-containing amino acid formed by a demethylation of METHIONINE. 2-amino-4-mercaptobutyric acid,Homocysteine, L-Isomer,2 amino 4 mercaptobutyric acid,Homocysteine, L Isomer,L-Isomer Homocysteine

Related Publications

S Y Hong, and D H Yang, and S K Chang
Association between plasma homocysteine concentrations and cardiac hypertrophy in end-stage renal disease.
January 1999, Journal of nephrology,
S Y Hong, and D H Yang, and S K Chang
Plasma reduced homocysteine concentrations are increased in end-stage renal disease.
January 2001, Kidney international,
S Y Hong, and D H Yang, and S K Chang
Plasma Amino Acid Concentrations Predict Mortality in Patients with End-Stage Liver Disease.
January 2016, PloS one,
S Y Hong, and D H Yang, and S K Chang
Assessing plasma total homocysteine in patients with end-stage renal disease.
January 2007, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
S Y Hong, and D H Yang, and S K Chang
Riboflavin is a determinant of total homocysteine plasma concentrations in end-stage renal disease patients.
May 2002, Journal of the American Society of Nephrology : JASN,
S Y Hong, and D H Yang, and S K Chang
Plasma homocysteine levels and cardiovascular mortality in patients with end-stage renal disease.
January 2004, Journal of nephrology,
S Y Hong, and D H Yang, and S K Chang
Plasma ascorbic acid concentrations in prevalent patients with end-stage renal disease on hemodialysis.
May 2015, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation,
S Y Hong, and D H Yang, and S K Chang
Comparative effects of hydroxocobalamin and cyanocobalamin on plasma homocysteine concentrations in end-stage renal disease.
October 2005, Metabolism: clinical and experimental,
S Y Hong, and D H Yang, and S K Chang
Elevated homocysteine levels in patients with end-stage renal disease.
November 2005, The Mount Sinai journal of medicine, New York,
S Y Hong, and D H Yang, and S K Chang
Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease.
March 1999, Journal of the American Society of Nephrology : JASN,
Copied contents to your clipboard!