-transparent.png){kind=logo}
BACKGROUND Na+/H+ exchange plays an important role in the ionic changes observed during myocardial ischemia and reperfusion. We investigated the cardioprotective efficacy of a selective Na+/H+ exchange inhibitor, 4-isopropyl-3-methylsulfonyl-benzoylguanidin-methanesulfonate (HOE642), in a canine model of long-term heart preservation. METHODS Canine donor hearts were stored for 24 hours in hyperkalemic crystalloid cardioplegic solution; in cardioplegic solution enriched with HOE642; in cardioplegic solution enriched with HOE642, with donor and recipient treated with HOE642; in standard cardioplegic solution, with donor and recipient treated with HOE642; or in standard cardioplegic solution, with only the recipient treated. After orthotopic transplantation, pressure-volume relationships were obtained and dogs were weaned from bypass. Morphology was studied. RESULTS Myocardial compliance was well preserved when donor and recipient were treated. These groups had the lowest myocardial water content, and no morphologic signs of irreversible damage. In these groups, weaning from cardiopulmonary bypass was successful in 10 of 10 animals, with a cardiac index around 2 L x min(-1) x m(-2). Only 3 of 5 animals in each of the other three groups could be weaned, with significantly lower cardiac indices. CONCLUSIONS Treatment with HOE642 in both donor and recipient improves myocardial compliance, postweaning cardiac index, and ultrastructure of donor hearts preserved for 24 hours and orthotopically transplanted.
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
November 1999,
Transplantation,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
February 2003,
Hypertension (Dallas, Tex. : 1979),
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
August 1995,
Circulation,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
August 1998,
The Annals of thoracic surgery,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
February 2005,
The Annals of thoracic surgery,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
October 2006,
The Journal of surgical research,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
February 2001,
American journal of physiology. Heart and circulatory physiology,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
November 1997,
Circulation,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
December 2003,
The Canadian journal of cardiology,
Y I Kim, and
P Herijgers, and
S K Laycock, and
A Van Lommel, and
E Verbeken, and
W J Flameng
August 2004,
American journal of physiology. Cell physiology,
