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An F2 intercross derived from C57BL/6 and DBA/2 progenitor inbred strains was used to test for replication of quantitative trait loci (QTLs) for alcohol preference nominated by a previous study using BXD recombinant inbred (RI) strains (Rodriguez et al., Alcohol. Clin. Exp. Res. 19:367-379, 1995). Fourteen provisional QTLs were nominated in the original RI study with a p < 0.05 criterion. In the present study, a genome scan (101 microsatellite markers) was conducted on an F2 population (n = 218). Three significant QTLs were detected on chromosomes 1, 4, and 9, and three suggestive QTLs were detected on chromosomes 2, 3, and 10. Of these six QTLs, four were consistent with the previous RI nominations. The replication rate of 28.6% (4 of 14) is in agreement with the results of simulation studies performed by Belknap et al. (Behav. Genet. 26:149-160, 1996) and supports the methodological argument for a multistage research design for nominating and replicating QTLs.
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
September 2003,
Psychiatric genetics,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
June 1996,
Nature genetics,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
July 1999,
Alcoholism, clinical and experimental research,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
August 1997,
Alcoholism, clinical and experimental research,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
March 2009,
Alcoholism, clinical and experimental research,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
November 2004,
Alcoholism, clinical and experimental research,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
December 1998,
Mammalian genome : official journal of the International Mammalian Genome Society,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
January 2005,
Genetics, selection, evolution : GSE,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
February 1997,
Genome research,
L M Tarantino, and
G E McClearn, and
L A Rodriguez, and
R Plomin
April 1995,
Alcoholism, clinical and experimental research,
