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OBJECTIVE To document the frequency and severity of reactions to antibiotics in children and adolescents with cystic fibrosis (CF), to determine which drugs and routes of administration are most likely to produce reactions and to assess how these reactions limit the choice of antibiotics. METHODS Medical records were reviewed to ascertain the number and routes of courses of antibiotics and all suspected drug reactions. Patients and their parents were interviewed about drug reactions. RESULTS Fifty-three records were suitable for analysis. Eighteen of 53 subjects had experienced a reaction (34%). The intravenous route was most allergenic, with 33% of treated patients experiencing a reaction and 9.5% of courses provoking a reaction. Piperacillin was the most allergenic antibiotic. CONCLUSIONS Drug hypersensitivity reactions are common in CF. Piperacillin is particularly allergenic. Whilst rarely life-threatening, the reactions are unpleasant and can limit our choices for antibiotic treatment of their bronchopneumonia.
R Wills, and
R L Henry, and
J L Francis
June 2018,
Paediatric respiratory reviews,
R Wills, and
R L Henry, and
J L Francis
April 1978,
Comprehensive therapy,
R Wills, and
R L Henry, and
J L Francis
February 2024,
Paediatric respiratory reviews,
R Wills, and
R L Henry, and
J L Francis
January 2020,
The journal of allergy and clinical immunology. In practice,
R Wills, and
R L Henry, and
J L Francis
January 2015,
Journal of biological regulators and homeostatic agents,
R Wills, and
R L Henry, and
J L Francis
July 1977,
Clinical allergy,
R Wills, and
R L Henry, and
J L Francis
November 2022,
British journal of clinical pharmacology,
R Wills, and
R L Henry, and
J L Francis
June 1984,
Lancet (London, England),
R Wills, and
R L Henry, and
J L Francis
February 1969,
The Medical letter on drugs and therapeutics,
R Wills, and
R L Henry, and
J L Francis
October 1984,
Drug intelligence & clinical pharmacy,
