-transparent.png){kind=logo}
Steroid hormone receptors control fundamental events in embryonic development and sex differentiation through their function as ligand-inducible transcription factors. The consequences of disrupting these processes can be especially profound during development due to the crucial role hormones play in controlling transient and irreversible developmental processes. Several environmental chemicals, including metabolites of the fungicide vinclozolin and the pesticide DDT, disrupt male reproductive development and function by inhibiting androgen receptor mediated events. A variety of in vitro and in vivo approaches have been used to determine the molecular basis of environmental antiandrogen toxicity. These chemicals commonly bind androgen receptor with moderate affinity and act as antagonists by inhibiting transcription of androgen dependent genes.
W R Kelce, and
L E Gray, and
E M Wilson
December 2016,
Reviews on environmental health,
W R Kelce, and
L E Gray, and
E M Wilson
November 1998,
Nihon rinsho. Japanese journal of clinical medicine,
W R Kelce, and
L E Gray, and
E M Wilson
July 2010,
Nature reviews. Endocrinology,
W R Kelce, and
L E Gray, and
E M Wilson
May 2022,
Gynecologie, obstetrique, fertilite & senologie,
W R Kelce, and
L E Gray, and
E M Wilson
January 2020,
Advances in anatomy, embryology, and cell biology,
W R Kelce, and
L E Gray, and
E M Wilson
December 2000,
Nihon rinsho. Japanese journal of clinical medicine,
W R Kelce, and
L E Gray, and
E M Wilson
February 2010,
Arquivos brasileiros de endocrinologia e metabologia,
W R Kelce, and
L E Gray, and
E M Wilson
January 2017,
Comptes rendus biologies,
W R Kelce, and
L E Gray, and
E M Wilson
January 2012,
Endocrine regulations,
W R Kelce, and
L E Gray, and
E M Wilson
January 2005,
Trends in endocrinology and metabolism: TEM,
