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The pharmacokinetics of theophylline following intravenous injection of aminophylline, 4 mg/kg of body weight, were determined in 30 children with asthma and in 6 normal adult volunteers. The average total clearance of theophylline was 87 ml/hr/kg in the children and 57 ml/hr/kg in the adults. The biologic half-life of theophylline in the children ranged from 1.42 to 7.85 hours, reflecting mainly pronounced interindividual differences in the elimination rate constant of the drug. There was no significant difference between the children and adults with respect to the distribution rate constants and apparent volumes of distribution of theophylline, but the elimination rate constant of the drug was considerably higher in children than in adults. Thus, children eliminate theophylline more rapidly on the average than do adults and also show pronounced interindividual differences in the elimination of the drug. Compared to adults, children tend to require relatively larger amounts of theophylline per day and the doses may have to be given at shorter intervals of time.
E F Ellis, and
R Koysooko, and
G Levy
January 1982,
La Pediatria medica e chirurgica : Medical and surgical pediatrics,
E F Ellis, and
R Koysooko, and
G Levy
January 1978,
Journal of medicine,
E F Ellis, and
R Koysooko, and
G Levy
September 1979,
European journal of clinical pharmacology,
E F Ellis, and
R Koysooko, and
G Levy
March 1985,
The Journal of allergy and clinical immunology,
E F Ellis, and
R Koysooko, and
G Levy
January 1986,
Farmakologiia i toksikologiia,
E F Ellis, and
R Koysooko, and
G Levy
January 1992,
Arerugi = [Allergy],
E F Ellis, and
R Koysooko, and
G Levy
November 1989,
Acta paediatrica Scandinavica,
E F Ellis, and
R Koysooko, and
G Levy
December 1994,
Asian Pacific journal of allergy and immunology,
E F Ellis, and
R Koysooko, and
G Levy
September 1984,
The Journal of the Arkansas Medical Society,
E F Ellis, and
R Koysooko, and
G Levy
September 1988,
Anales espanoles de pediatria,
