Age-related changes in blood lymphocyte subsets of Saudi Arabian healthy children. 1998

S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
Division of Immunology, Department of Pathology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh 11461, Kingdom of Saudi Arabia. shahab@welchlink.welch.jhu.edu

The age-related changes in absolute and percentage values of lymphocyte subsets in the peripheral blood of healthy children of different ages (1 month to 13 years) were studied by flow cytometry. The absolute and percentage values for most lymphocyte subpopulations differed substantially with age. Comparisons among age groups from infants through adults revealed progressive declines in the absolute numbers of leukocytes, total lymphocytes, and T, B, and natural killer (NK) cells. The percentages of T cells increased with age. Within the T-lymphocyte population, the CD8(+) subset increased but the CD4(+) subset decreased, resulting in a declining CD4(+)/CD8(+) ratio. The percentage of B cells declined, but that of NK cells remained unchanged. The percentage of HLA-DR+ T cells increased over time, but their number changed inconsistently. Our findings confirm and extend earlier reports on age-related changes in lymphocyte subpopulations. These data should be useful in the interpretation of disease-related changes, as well as therapy-dependent alterations, in lymphocyte subsets in children of different age groups.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007694 Killer Cells, Natural Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008297 Male Males
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D005434 Flow Cytometry Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake. Cytofluorometry, Flow,Cytometry, Flow,Flow Microfluorimetry,Fluorescence-Activated Cell Sorting,Microfluorometry, Flow,Cell Sorting, Fluorescence-Activated,Cell Sortings, Fluorescence-Activated,Cytofluorometries, Flow,Cytometries, Flow,Flow Cytofluorometries,Flow Cytofluorometry,Flow Cytometries,Flow Microfluorometries,Flow Microfluorometry,Fluorescence Activated Cell Sorting,Fluorescence-Activated Cell Sortings,Microfluorimetry, Flow,Microfluorometries, Flow,Sorting, Fluorescence-Activated Cell,Sortings, Fluorescence-Activated Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
November 2000, Clinical and diagnostic laboratory immunology,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
November 1998, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
January 2003, The National medical journal of India,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
July 2009, Science in China. Series C, Life sciences,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
April 1999, Scandinavian journal of clinical and laboratory investigation,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
January 2004, The Turkish journal of pediatrics,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
May 2020, Journal of clinical laboratory analysis,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
April 2002, American journal of veterinary research,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
December 2015, Cytometry. Part A : the journal of the International Society for Analytical Cytology,
S Shahabuddin, and I Al-Ayed, and M O Gad El-Rab, and M I Qureshi
July 1998, Experimental animals,
Copied contents to your clipboard!