-transparent.png){kind=logo}
A series of mono-glycoloylamino derivatives was synthesized by treatment of the corresponding aromatic monoamine derivatives with glycoloyl chloride derivatives in pyridine or dichloromethane, in the presence of a base such as triethylamine or pyridine. Hydrolysis of acetoxy compounds in aqueous ammonia and methanol solution produced hydroxy derivatives with ease. These compounds were tested in the rat PCA (passive cutaneous anaphylaxis) assay by oral administration. Thiazole and thiadiazole derivatives showed moderate inhibition in this assay. In contrast, benzothiazole and benzonitrile derivatives exhibited marked inhibition. In particular, compound 5t also showed marked inhibition of eosinophil adhesion to TNF (tumor necrosis factor) -alpha-treated HUVEC (human umbilical vein endothelial cells) in the range of 10(-8)-10(-5) M.
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
January 1990,
Chemical & pharmaceutical bulletin,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
May 2002,
Chemical & pharmaceutical bulletin,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
June 1994,
Journal of medicinal chemistry,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
December 1994,
Chemical & pharmaceutical bulletin,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
August 2010,
Bioorganic & medicinal chemistry letters,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
September 1992,
Chemical & pharmaceutical bulletin,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
October 1987,
Il Farmaco; edizione scientifica,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
January 2024,
Frontiers in chemistry,
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
August 1999,
Farmaco (Societa chimica italiana : 1989),
M Ban, and
H Taguchi, and
T Katsushima, and
M Takahashi, and
K Shinoda, and
A Watanabe, and
T Tominaga
June 1997,
Bollettino chimico farmaceutico,
