Biomaterial Database

Multiple synaptic connections of a single neuron change differentially with age. 1998

L J Klaassen, and C Janse, and M van der Roest

Graduate School Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit Amsterdam, Faculty of Biology, The Netherlands.

The efficacy of chemical synaptic connections of a single identified interneuron with different types of follower neurons was studied throughout the adult life of the pond snail Lymnaea stagnalis. Simultaneous intracellular recordings were made from the interneuron RPeD1 and its follower neurons in isolated CNS preparations from animals of different age groups (3-18 months of age). The presence of postsynaptic responses to RPeD1 action potentials was tested. With increasing age, the number of A-group neurons that was found with a response to evoked RPeD1 action potentials decreased, yet the number of HIJK-group neurons responding to RPeD1 input increased. The number of G-group neurons and the number of individual neurons VD2/3 and VD4 with RPeD1 input did not differ significantly between age groups. However, there was variability in the presence of responses in these individual neurons. Thus, synaptic connections of the single interneuron RPeD1 change differentially throughout the adult life of L. stagnalis. Within the A-group we found indications that changes in RPeD1 input apply to the entire A-group. In the A-group neurons changes in several electrical properties could not account for the observed age-related changes in the number of neurons responding to RPeD1 action potentials.

UI	MeSH Term	Description	Entries
D008195	Lymnaea	A genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes.	Lymnea,Lymnaeas,Lymneas
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002490	Central Nervous System	The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.	Cerebrospinal Axis,Axi, Cerebrospinal,Axis, Cerebrospinal,Central Nervous Systems,Cerebrospinal Axi,Nervous System, Central,Nervous Systems, Central,Systems, Central Nervous
D004594	Electrophysiology	The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013569	Synapses	Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.	Synapse
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In