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Experiments on rats of the Wistar strain has shown that preliminary repeated introduction of phenobarbitals and chlordiazepoxide weakens the pharmacological effect of medications, increases the liver weight and the protein content, RNA, R-450 cytochrome, accelerates the oxidation of substrates, but to a higher degree of hexobarbital. Aminazine and mellipramine do not significantly influence these indices changing, however, the affinity of R-450 cytochrome to different substrates and the speed of their oxidation.
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