BACKGROUND This retrospective study was undertaken to determine the mechanism by which cardiac tamponade (CT) occurs after placement of central venous catheters (CVC), and to determine if physicians are aware of this potentially lethal complication. METHODS Twenty-five previously unreported cases of CT from CVC were reviewed. The chest radiographs and postmortem records were reviewed when available. Two hundred physicians were interviewed about their knowledge of CT from CVC. They were specifically asked if they had reviewed the three-volume video, "CVC Complications," that was sent by the Food and Drug Administration to all hospitals where CVC are inserted. RESULTS All postinsertion chest radiographs showed the tip of the catheter to be within the pericardial silhouette. All patients developed unexplained hypotension from hours to 1 week after CVC placement. Eight patients complained of chest tightness, 12 of shortness of breath, and 15 were noted to have air hunger. The electrocardiogram showed inferior wall injury in 7 patients. None of the physicians surveyed had seen the FDA video. CONCLUSIONS Cardiac tamponade from central venous catheters is preventable if the tip of the catheter is outside the cardiac silhouette on chest radiograph. Any patient with a CVC in place who develops unexplained hypotension, chest tightness, or shortness of breath should have an emergency echocardiogram to rule out cardiac tamponade.