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Thermal inactivation of Venezuelan Equine Encephalomyelitis Virus (VEEV) was studied at temperatures from 26 degrees to 55 degrees C. Inactivation of infectivity took place by two thermodynamically different reactions, one of which predominated at temperatures below 44 degrees C and the other at higher temperatures. The presence of 1 or 2 M NaCl stabilized the VEE virus at low temperatures but enhanced the inactivation at high temperatures. This latter effect at temperatures higher than 50 degrees C, is associated with the occurrence of two-component survival curves. The different effects of hypertonic NaCl concentrations at the two ranges of temperature, are related to different mechanisms of inactivation operating at each range (protein denaturation and nucleic acid-RNA breakdown). Different kinetics of thermal inactivation at 55 degrees C were observed between virus strains with different virulence. However, no significant correlations was found between the virulence of the eleven VEE virus strains studied and their thermostability at 37 degres and 55 degrees C.
R Walder, and
F Liprandi
November 1967,
Applied microbiology,
R Walder, and
F Liprandi
January 1983,
Comparative immunology, microbiology and infectious diseases,
R Walder, and
F Liprandi
October 1985,
Applied and environmental microbiology,
R Walder, and
F Liprandi
January 1971,
Voprosy virusologii,
R Walder, and
F Liprandi
October 1969,
Journal of virology,
R Walder, and
F Liprandi
October 1965,
Virology,
R Walder, and
F Liprandi
July 1961,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R Walder, and
F Liprandi
January 1970,
Voprosy virusologii,
R Walder, and
F Liprandi
June 1973,
Infection and immunity,
R Walder, and
F Liprandi
January 1971,
Biokhimiia (Moscow, Russia),
