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Lysophosphatidylcholine upregulates CD40 ligand expression in newly activated human CD4+ T cells. 1998
S Sakata-Kaneko, and
Y Wakatsuki, and
T Usui, and
Y Matsunaga, and
T Itoh, and
E Nishi, and
N Kume, and
T Kita
Department of Clinical Bio-regulatory Science, Kyoto University Graduate School of Medicine, Japan.
Lysophosphatidylcholine (lyso-PC) accumulates in tissues undergoing inflammation and atherosclerosis, where an infiltration of T cells is also seen. We found that lyso-PC increased IFN-gamma production and CD40L expression in CD4+ T cells stimulated with anti-CD3 Ab and recombinant CD80 molecules, whereas lyso-PC did not affect IL-2 and IL-4 production. These results suggest that lyso-PC, in combination with other stimuli, may regulate CD4+ T cell functions to propagate local inflammatory reactions and also imply a novel role played by a modified lipid in the selection of Th1/Th2 immune response as well as in the T cell mediated pathogenesis in atherosclerosis.
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