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A phase I trial of a 24-hour infusion of paclitaxel was conducted to identify the maximum tolerated dose of paclitaxel with granulocyte colony-stimulating factor (G-CSF) in patients with unresectable malignancy previously untreated with chemotherapy. Nineteen patients with metastatic melanoma or non-small cell lung cancer were treated with paclitaxel administered at 250, 300, 400 mg/m2 every 3 weeks. G-CSF, 5 microg/kg was given as a daily subcutaneous injection 24 hours after the completion of the infusion. Dose limiting myelosuppression and peripheral neuropathy was observed at 400 mg/m2 and 350 mg/m2. Paclitaxel can be safely administered as a 24-hour infusion at 300 mg/m2 with G-CSF. Further studies of paclitaxel and G-CSF are recommended to determine a dose-response relationship in sensitive tumors.
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
March 1995,
Nihon rinsho. Japanese journal of clinical medicine,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
November 1999,
Nihon rinsho. Japanese journal of clinical medicine,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
July 2010,
Nihon rinsho. Japanese journal of clinical medicine,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
August 2005,
Nihon rinsho. Japanese journal of clinical medicine,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
July 1992,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
August 1994,
The Journal of dermatology,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
January 1996,
Enfermedades infecciosas y microbiologia clinica,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
September 1991,
Bone marrow transplantation,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
January 1993,
Journal of the National Cancer Institute. Monographs,
A I Einzig, and
P H Wiernik, and
S Wadler, and
J Kaplan, and
L T Benson, and
L Tentoramano, and
V Tan
October 1994,
Seminars in oncology,
