Functional and morphologic reactions of peri-implant bone surrounding screw implants (Bonefit) were studied in three dogs by loading the implants with continuous forces of 2 (about 204 gm) and 5 N (about 510 gm). Eight implants were inserted to an endosseous length of 12 mm and placed about 10 mm apart in the region of the lower premolars. The fixtures healed in a closed environment for 12 weeks, after which they were uncovered and loaded with abutments and orthodontic devices to produce horizontal distraction with a force of 2 N (about 204 gm) for 12 weeks. Subsequently they were loaded with 5 N (about 510 gm) for another 24 weeks. The distance between and the mobility of the implants were determined before and after each phase of experimental loading. Fixtures of the same type that were osseointegrated and not exposed, or osseointegrated and loaded by mastication, were used as a control. Animals were euthanized and specimens sectioned. The result was that continuously loaded implants showed no significant displacement for any force level. The mobility of the fixtures increased slightly by about 1 Periotest-value (PTV) at the end of the experiment. No significant peri-implant pocket could be seen in implants loaded by continuous or masticatory forces. Histologic and morphometric evaluation indicated compaction of bone as a result of loading. Osseointegrated implants have potential as a firm osseous anchorage for orthodontic treatment and can resist continuous horizontal forces of at least 5 N (about 510 gm) during a period of several months.