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Benzodiazepine receptor binding was assessed in four Japanese men with Machado-Joseph disease. METHODS The distribution of benzodiazepine receptors was measured by radionuclide imaging (SPECT) after intravenous administration of 123I-iomazenil (Ro 16-0154). RESULTS SPECT demonstrated decreased binding throughout the cerebral cortex and cerebellum in all patients. Binding potential (receptor concentration x affinity) was diffusely decreased in cerebral cortex, thalamus, striatum and cerebellum compared with control subjects, suggesting that GABAergic function may be decreased globally in these patients. Cerebral blood flow was largely normal, and no cerebral cortical atrophy was evident on MRI. CONCLUSIONS Iodine-123-iomazenil SPECT may become a potent method for detecting impairment of the cerebral cortex even before brain perfusion SPECT or MRI can reveal early abnormalities.
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
June 2000,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
January 1995,
Clinical neuroscience (New York, N.Y.),
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
October 1995,
No to shinkei = Brain and nerve,
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
January 2005,
Servir (Lisbon, Portugal),
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
January 1999,
Ryoikibetsu shokogun shirizu,
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
January 2001,
Ryoikibetsu shokogun shirizu,
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
October 1996,
Journal of the neurological sciences,
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
April 1988,
Rhode Island medical journal,
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
June 1991,
Archives of neurology,
M Ishibashi, and
T Sakai, and
T Matsuishi, and
Y Yonekura, and
Y Yamashita, and
T Abe, and
Y Ohnishi, and
N Hayabuchi
May 2012,
Progress in neurobiology,
