Biomaterial Database

Spontaneous remission in patients with essential blepharospasm and Meige syndrome. 1998

A Castelbuono, and N R Miller

Neuro-Ophthalmology Unit, The Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

OBJECTIVE To determine the frequency of remission in patients with essential blepharospasm and Meige syndrome. METHODS Retrospective analysis of patients by means of questionnaire in an institutional setting. RESULTS Among 238 patients diagnosed in a single institution as having essential blepharospasm or Meige syndrome, 27 (11.3%) claimed to be symptom free without curative surgery. The average time between onset and resolution in the patients who claimed remission was 4.85 years (range, 3 months to 22 years). Among these patients, the duration of remission averaged 6.33 years (range, 1 year to 14 years). CONCLUSIONS Patients with essential blepharospasm or Meige syndrome have a small but definite potential for spontaneous remission of symptoms, particularly within the first 5 years after onset of symptoms.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008538	Meige Syndrome	A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108)	Blepharospasm-Oromandibular Dystonia,Brueghel Syndrome,Idiopathic Orofacial Dyskinesia,Blepharospasm-Oromandibular Dyskinesia,Blepharospasm-Oromandibular Dystonia Syndrome,Blepharospasm-Oromandibular Dystonia Syndrome, Idiopathic,Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome,Syndrome, Blepharospasm-Oromandibular Dystonia,Blepharospasm Oromandibular Dyskinesia,Blepharospasm Oromandibular Dystonia,Blepharospasm Oromandibular Dystonia Syndrome,Blepharospasm Oromandibular Dystonia Syndrome, Idiopathic,Blepharospasm-Oromandibular Dyskinesias,Blepharospasm-Oromandibular Dystonia Syndromes,Blepharospasm-Oromandibular Dystonias,Dyskinesia, Blepharospasm-Oromandibular,Dyskinesia, Idiopathic Orofacial,Dyskinesias, Blepharospasm-Oromandibular,Dyskinesias, Idiopathic Orofacial,Dystonia Syndrome, Blepharospasm-Oromandibular,Dystonia Syndromes, Blepharospasm-Oromandibular,Dystonia, Blepharospasm-Oromandibular,Dystonias, Blepharospasm-Oromandibular,Idiopathic Blepharospasm Oromandibular Dystonia Syndrome,Idiopathic Orofacial Dyskinesias,Orofacial Dyskinesia, Idiopathic,Orofacial Dyskinesias, Idiopathic
D011795	Surveys and Questionnaires	Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions.	Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D012075	Remission, Spontaneous	A spontaneous diminution or abatement of a disease over time, without formal treatment.	Spontaneous Healing,Spontaneous Regression,Spontaneous Remission,Healing, Spontaneous,Regression, Spontaneous,Spontaneous Healings,Spontaneous Regressions
D001764	Blepharospasm	Excessive winking; tonic or clonic spasm of the orbicularis oculi muscle.	Blepharospasms
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor