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Chromosome 11p15.5 harbors a gene or genes involved in Beckwith-Wiedemann syndrome that confer(s) susceptibility to Wilms' tumor, rhabdomyosarcoma, and hepatoblastoma. We have previously identified a transcript at 11p15.5 which encodes a putative membrane transport protein, designated organic cation transporter-like 2 (ORCTL2), that shares homology with tetracycline resistance proteins and bacterial multidrug resistance proteins. In this report, we have investigated the transport properties of ORCTL2 and show that this protein can confer resistance to chloroquine and quinidine when overexpressed in bacteria. Immunohistochemistry analyses performed with anti-ORCTL2 polyclonal antibodies on human renal sections indicate that ORCTL2 is localized on the apical membrane surface of the proximal tubules. These results suggest that ORCTL2 may play a role in the transport of chloroquine and quinidine related compounds in the kidney.
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
November 2000,
American journal of physiology. Renal physiology,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
August 2014,
Pflugers Archiv : European journal of physiology,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
April 2017,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
November 2005,
The Journal of pharmacology and experimental therapeutics,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
May 2000,
Pflugers Archiv : European journal of physiology,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
February 2006,
The Journal of pharmacology and experimental therapeutics,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
May 1996,
The American journal of physiology,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
September 1988,
The American journal of physiology,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
November 2005,
The Journal of pharmacology and experimental therapeutics,
M Reece, and
D Prawitt, and
J Landers, and
C Kast, and
P Gros, and
D Housman, and
B U Zabel, and
J Pelletier
June 1997,
The Journal of biological chemistry,
