BIOMAT Database Logo BIOMAT Database Logo

Effect of DEHP [di-(2-ethyl hexyl) phthalate] on lipid peroxidation in liver in rats and in primary cultures of rat hepatocytes. 1998

A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Department of Biological Sciences, Peninsula Polymers Limited, Thiruvananthapuram.

The effect of DEHP [di-(2-ethly hexyl) phthalate] on lipid peroxidation in the liver in rats and in primary cultures of rat hepatocytes incubated with it was studied. The doses of DEHP used in this study corresponded to the low levels of this substance leaching into blood stored in DEHP plasticised PVC bags. Increased activity of superoxide dismutase (SOD) and catalase, increased concentration of malondialdehyde (MDA) and conjugated dienes and decrease in the concentration of glutathione and vitamin E have been observed in the liver of rats administered DEHP. Primary cultures of rat hepatocytes incubated with DEHP also showed increase in the activity of these enzymes, increase in the concentration of MDA and decrease in vitamin E. These results indicate that DEHP promotes lipid peroxidation. Incorporation of vitamin E along with DEHP into the culture medium containing hepatocytes counteracted these effects.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D002374 Catalase An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA. Catalase A,Catalase T,Manganese Catalase,Mn Catalase
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004051 Diethylhexyl Phthalate An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers. Dioctyl Phthalate,Bis(2-ethylhexyl)phthalate,DEHP,Di(2-ethylhexyl)phthalate,Di-2-Ethylhexylphthalate,Di 2 Ethylhexylphthalate,Phthalate, Diethylhexyl,Phthalate, Dioctyl
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013482 Superoxide Dismutase An oxidoreductase that catalyzes the reaction between SUPEROXIDES and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. Hemocuprein,Ag-Zn Superoxide Dismutase,Cobalt Superoxide Dismutase,Cu-Superoxide Dismutase,Erythrocuprein,Fe-Superoxide Dismutase,Fe-Zn Superoxide Dismutase,Iron Superoxide Dismutase,Manganese Superoxide Dismutase,Mn-SOD,Mn-Superoxide Dismutase,Ag Zn Superoxide Dismutase,Cu Superoxide Dismutase,Dismutase, Ag-Zn Superoxide,Dismutase, Cobalt Superoxide,Dismutase, Cu-Superoxide,Dismutase, Fe-Superoxide,Dismutase, Fe-Zn Superoxide,Dismutase, Iron Superoxide,Dismutase, Manganese Superoxide,Dismutase, Mn-Superoxide,Dismutase, Superoxide,Fe Superoxide Dismutase,Fe Zn Superoxide Dismutase,Mn SOD,Mn Superoxide Dismutase,Superoxide Dismutase, Ag-Zn,Superoxide Dismutase, Cobalt,Superoxide Dismutase, Fe-Zn,Superoxide Dismutase, Iron,Superoxide Dismutase, Manganese
D014810 Vitamin E A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
D015227 Lipid Peroxidation Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor. Lipid Peroxidations,Peroxidation, Lipid,Peroxidations, Lipid
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats

Related Publications

A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Effect of di-2-ethylhexyl phthalate (DEHP) on glycogen metabolism in rat liver.
January 1980, Toxicology,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Hepatic studies of intraperitoneally administered tris(2-ethyl hexyl)trimellitate (TOTM) and di(2-ethyl hexyl)phthalate in rats.
February 1990, Journal of applied toxicology : JAT,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Effect of di-2-ethylhexyl phthalate (DEHP) on rat gonads.
October 1976, Environmental research,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
The effects of di 2-ethyl hexyl phthalate (DEHP) on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level.
May 2017, Toxicology mechanisms and methods,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Effect of di(2-ethylhexyl)phthalate (DEHP) on spermatogenesis in adult rats.
December 1986, Toxicology,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Effect of the dietary exposure of rat to di(2-ethyl hexyl) phthalate on their metabolic efficiency.
November 2002, Food additives and contaminants,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Effect of Di-(2-ethylhexyl) phthalate (DEHP) on chemical constituents and enzymatic activity of rat liver.
November 1978, Toxicology,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Lack of genotoxic activity of di(2-ethylhexyl)phthalate (DEHP) in rat and human hepatocytes.
October 1984, Carcinogenesis,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
[Behavioral changes of rats after short-term exposure to di-(2-ethyl hexyl) phthalate].
March 2013, Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
A Santhosh, and K G Nair, and P Arun, and K V Deepadevi, and V Manojkumar, and L R Lakshmi, and P A Kurup
Di (2-ethyl hexyl) phthalate (DEHP)-induced spleen toxicity in quail (Coturnix japonica) via disturbing Nrf2-mediated defense response.
August 2019, Environmental pollution (Barking, Essex : 1987),
Copied contents to your clipboard!