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A 61-year-old woman presented with high fever, headache and left facial palsy with diplopia. Histopathological examination of the biopsied specimens taken from nasal mucosa and kidney revealed a granulomatous angiitis with giant cell infiltration. Ga-DTPA-enhanced magnetic resonance imaging (MRI) revealed a thickening of dura mater in the middle cranial fossa and tentorium cerebelli. The observed left facial and occulomotor palsy was considered to be caused by pachymeningitis associated with Wegener's granulomatosis (WG). Cyclophosphamide combined with prednisolone effectively improved the symptoms. However, the patient died of acute interstitial pneumonitis, presumably caused by cyclophosphamide. The pathohistology obtained in the autopsy revealed a fibrous thickening of the dura mater in the left meningen with a segmental scarring of the arteries and a necrotizing arteritis in the kidney.
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
April 1976,
Rinsho shinkeigaku = Clinical neurology,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
July 2000,
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
April 2009,
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
December 2002,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
May 1970,
Nihon Jibiinkoka Gakkai kaiho,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
November 1970,
Saishin igaku. Modern medicine,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
November 1973,
Nihon rinsho. Japanese journal of clinical medicine,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
November 1998,
Australasian radiology,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
September 2003,
The Journal of rheumatology,
J Tojo, and
T Nishimaki, and
H Ohyanagi, and
A Saito, and
H Ohira, and
M Saka, and
M Kuroda, and
H Ishikawa, and
R Kasukawa
October 1970,
Saishin igaku. Modern medicine,
