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We have used the perfused guinea-pig temporal-bone preparation to study the sound-evoked efflux of aspartate and glutamate, which are putative afferent transmitters in the cochlea. The cochlea was stimulated with white noise at 89, 95, and 101 dB SPL. Cochlear function was monitored by recording the endocochlear potential, the cochlear microphonic, and the summating potential. In silence, there was a low basal efflux of both amino acids. A significant and intensity dependent sound-evoked efflux of aspartate was observed at all levels, whereas a significant efflux of glutamate was found only at the 101 dB SPL level. Immunohistochemistry of sections from the organ of corti showed an ubiquitous distribution of glutamate-like immunoreactivity in the sensory organ and ganglion, whereas aspartate-like immunoreactivity was found in the region of the inner hair cells and in the spiral ganglion. In view of these findings, we suggest that not only glutamate, but also aspartate may have a neurotransmitter role in the afferent pathway of the cochlea.
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M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
December 1987,
Hearing research,
W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
January 1998,
Acta oto-laryngologica. Supplementum,
W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
February 1976,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
March 1991,
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W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
June 1985,
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W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
September 1986,
The Journal of physiology,
W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
February 1999,
Chinese medical journal,
W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
June 1969,
Obstetrics and gynecology,
W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
January 1985,
Experimental brain research,
W Jäger, and
M Goiny, and
M Herrera-Marschitz, and
A Flock, and
T Hökfelt, and
L Brundin
April 1994,
Hearing research,
